| SP | Martinez, P.Martinez, Pedro $$ >> | 29 | 2000 | R | 100 | 14 | 14 | 3 | 8 | 3.68 | .280 | 1.16 | 7.5 | 3.0 | 8.7 | 102.2 | 85 | 42 | 42 | 13 | 34 | 99 | 2 | 0 | 0 | 1 | 8 | 1 | 1 | 3.75 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 14 | 14 | 2 | 8 | 4.61 | .312 | 1.35 | 8.7 | 3.5 | 7.1 | 80.0 | 77 | 41 | 41 | 7 | 31 | 63 | 0 | 0 | 0 | 0 | 8 | 1 | 1 | 3.76 |
| CL | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 24 | 0 | 1 | 6 | 6.14 | .365 | 1.73 | 8.2 | 7.4 | 9.4 | 22.0 | 20 | 15 | 15 | 1 | 18 | 23 | 0 | 10 | 3 | 0 | 0 | 0 | 3 | 3.95 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 28 | 0 | 0 | 2 | 3.78 | .296 | 1.23 | 6.5 | 4.6 | 8.7 | 33.1 | 24 | 14 | 14 | 4 | 17 | 32 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 4.27 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 38 | 0 | 1 | 1 | 3.56 | .283 | 1.16 | 7.1 | 3.3 | 7.7 | 43.0 | 34 | 18 | 17 | 6 | 16 | 37 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.28 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 14 | 0 | 2 | 0 | 1.47 | .295 | 1.15 | 5.0 | 5.5 | 8.0 | 18.1 | 10 | 3 | 3 | 0 | 11 | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 3.39 |