| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 29 | 29 | 16 | 7 | 2.94 | .273 | 1.09 | 7.3 | 2.6 | 8.2 | 186.2 | 150 | 71 | 61 | 17 | 54 | 170 | 1 | 0 | 0 | 1 | 17 | 6 | 0 | 3.33 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 27 | 27 | 9 | 12 | 5.53 | .333 | 1.50 | 10.5 | 3.0 | 7.0 | 138.1 | 161 | 90 | 85 | 21 | 46 | 108 | 0 | 0 | 0 | 0 | 11 | 0 | 8 | 4.41 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 76 | 27 | 27 | 5 | 17 | 5.85 | .334 | 1.49 | 10.2 | 3.2 | 5.0 | 152.1 | 173 | 105 | 99 | 27 | 54 | 84 | 3 | 0 | 0 | 1 | 9 | 2 | 5 | 5.31 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 28 | 27 | 6 | 16 | 6.25 | .356 | 1.63 | 11.1 | 3.7 | 4.0 | 149.2 | 183 | 115 | 104 | 17 | 61 | 67 | 1 | 0 | 0 | 0 | 11 | 4 | 6 | 4.89 |
| SU | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 94 | 59 | 0 | 3 | 0 | 3.13 | .294 | 1.25 | 7.3 | 3.9 | 9.4 | 69.0 | 56 | 26 | 24 | 6 | 30 | 72 | 0 | 5 | 3 | 0 | 0 | 0 | 3 | 3.35 |
| CL | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 87 | 58 | 0 | 4 | 4 | 4.06 | .319 | 1.40 | 10.0 | 2.6 | 7.4 | 62.0 | 69 | 30 | 28 | 7 | 18 | 51 | 0 | 32 | 4 | 0 | 0 | 0 | 0 | 3.69 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 72 | 0 | 1 | 0 | 2.63 | .264 | 1.06 | 6.4 | 3.3 | 9.1 | 85.2 | 60 | 25 | 25 | 7 | 31 | 86 | 0 | 1 | 0 | 0 | 0 | 1 | 5 | 3.18 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 61 | 0 | 5 | 1 | 3.42 | .299 | 1.24 | 8.4 | 2.8 | 8.9 | 71.0 | 66 | 28 | 27 | 10 | 22 | 70 | 0 | 1 | 2 | 0 | 0 | 3 | 3 | 3.92 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 46 | 0 | 3 | 0 | 2.67 | .263 | 1.05 | 6.2 | 3.5 | 5.1 | 60.2 | 41 | 21 | 18 | 4 | 23 | 34 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 3.93 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 38 | 0 | 3 | 0 | 4.15 | .343 | 1.56 | 10.6 | 3.5 | 6.9 | 39.0 | 46 | 18 | 18 | 3 | 15 | 30 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.62 |