| SP | Buehler, W.Buehler, Walker >> | 26 | 2021 | R | 100 | 30 | 30 | 19 | 6 | 2.67 | .262 | 1.05 | 7.1 | 2.4 | 8.1 | 202.1 | 160 | 64 | 60 | 10 | 53 | 182 | 4 | 0 | 0 | 2 | 21 | 3 | 4 | 2.67 |
| SP | Skubal, T.Skubal, Tarik >> | 25 | 2022 | L | 88 | 29 | 29 | 14 | 10 | 4.07 | .322 | 1.40 | 9.6 | 3.1 | 7.8 | 170.1 | 181 | 80 | 77 | 23 | 58 | 147 | 0 | 0 | 0 | 0 | 13 | 4 | 1 | 4.12 |
| SP | Estes, S.Estes, Shawn # >> | 24 | 1997 | L | 70 | 28 | 28 | 10 | 9 | 4.26 | .292 | 1.22 | 7.7 | 3.3 | 6.0 | 177.1 | 152 | 89 | 84 | 18 | 65 | 118 | 1 | 0 | 0 | 1 | 16 | 2 | 9 | 4.12 |
| SP | Dempster, R.Dempster, Ryan # >> | 32 | 2009 | R | 57 | 27 | 27 | 8 | 12 | 5.39 | .333 | 1.48 | 10.1 | 3.3 | 5.9 | 160.1 | 179 | 99 | 96 | 24 | 58 | 104 | 2 | 0 | 0 | 0 | 11 | 3 | 8 | 4.79 |
| RP | Iglesias, R.Iglesias, Raisel >> | 27 | 2017 | R | 86 | 69 | 0 | 2 | 1 | 3.30 | .289 | 1.22 | 7.6 | 3.4 | 8.1 | 76.1 | 64 | 29 | 28 | 8 | 29 | 68 | 0 | 9 | 2 | 0 | 0 | 0 | 0 | 3.72 |
| RP | Steckenrider, D.Steckenrider, Drew >> | 30 | 2021 | R | 85 | 42 | 0 | 4 | 2 | 3.64 | .273 | 1.13 | 6.1 | 4.0 | 5.9 | 47.0 | 32 | 19 | 19 | 8 | 21 | 31 | 0 | 8 | 0 | 0 | 0 | 0 | 0 | 5.23 |
| RP | Lavelle, G.Lavelle, Gary >> | 34 | 1983 | L | 78 | 70 | 0 | 3 | 4 | 3.35 | .294 | 1.23 | 8.3 | 2.9 | 4.1 | 53.2 | 49 | 22 | 20 | 7 | 17 | 24 | 0 | 6 | 1 | 0 | 0 | 1 | 2 | 4.83 |
| RP | Valverde, J.Valverde, Jose >> | 32 | 2011 | R | 75 | 27 | 0 | 1 | 0 | 3.56 | .289 | 1.22 | 5.4 | 5.7 | 5.4 | 30.1 | 18 | 12 | 12 | 2 | 19 | 18 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.57 |