| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 56 | 8 | 8 | 4 | 1 | 3.71 | .285 | 1.16 | 7.6 | 2.8 | 6.0 | 51.0 | 43 | 25 | 21 | 5 | 16 | 34 | 0 | 0 | 0 | 0 | 5 | 2 | 3 | 4.00 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 41 | 8 | 8 | 2 | 5 | 6.03 | .333 | 1.47 | 10.0 | 3.4 | 7.1 | 37.1 | 41 | 25 | 25 | 6 | 14 | 29 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 4.76 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 90 | 23 | 0 | 0 | 2 | 3.57 | .358 | 1.68 | 9.8 | 5.7 | 14.3 | 22.2 | 24 | 10 | 9 | 3 | 14 | 35 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.50 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 59 | 23 | 0 | 2 | 1 | 4.26 | .283 | 1.14 | 9.4 | 1.1 | 9.4 | 25.1 | 26 | 12 | 12 | 3 | 3 | 26 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 2.96 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 32 | 2004 | R | 41 | 20 | 0 | 0 | 1 | 3.91 | .317 | 1.35 | 6.3 | 5.9 | 5.9 | 23.0 | 16 | 10 | 10 | 4 | 15 | 15 | 0 | 2 | 0 | 0 | 0 | 1 | 3 | 6.04 |
| RP | Cordero, F.Cordero, Francisco >> | 32 | 2007 | R | 26 | 16 | 0 | 0 | 2 | 3.26 | .293 | 1.19 | 9.0 | 1.9 | 9.5 | 19.1 | 19 | 7 | 7 | 1 | 4 | 20 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 2.37 |
| RP | Wickman, B.Wickman, Bob >> | 32 | 2001 | R | 15 | 10 | 0 | 1 | 0 | 5.91 | .347 | 1.59 | 12.6 | 2.7 | 4.5 | 10.2 | 14 | 7 | 7 | 4 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8.10 |
| SP | Volquez, E.Volquez, Edinson >> | 25 | 2008 | R | 26 | 4 | 0 | 1 | 0 | 1.29 | .276 | 1.07 | 4.5 | 5.1 | 9.0 | 14.0 | 7 | 2 | 2 | 1 | 8 | 14 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.86 |