| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 21 | 21 | 9 | 10 | 4.33 | .338 | 1.52 | 8.2 | 5.6 | 9.6 | 120.2 | 109 | 60 | 58 | 12 | 74 | 128 | 0 | 0 | 0 | 0 | 7 | 2 | 4 | 4.07 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 70 | 21 | 21 | 10 | 7 | 5.17 | .338 | 1.49 | 10.4 | 3.1 | 5.4 | 132.1 | 152 | 78 | 76 | 19 | 45 | 79 | 2 | 0 | 0 | 2 | 9 | 6 | 5 | 4.83 |
| SP | Beckett, J.Beckett, Josh # >> | 27 | 2007 | R | 49 | 20 | 20 | 8 | 7 | 4.71 | .281 | 1.14 | 8.2 | 2.1 | 7.9 | 126.0 | 115 | 70 | 66 | 15 | 29 | 111 | 3 | 0 | 0 | 1 | 12 | 4 | 1 | 3.57 |
| SP | Jimenez, U.Jimenez, Ubaldo | 25 | 2009 | R | 35 | 20 | 20 | 5 | 9 | 4.45 | .348 | 1.57 | 8.6 | 5.6 | 6.4 | 115.1 | 110 | 59 | 57 | 9 | 71 | 82 | 0 | 0 | 0 | 0 | 6 | 4 | 2 | 4.55 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 65 | 0 | 2 | 1 | 2.49 | .267 | 1.08 | 6.9 | 2.9 | 8.9 | 72.1 | 55 | 21 | 20 | 5 | 23 | 71 | 0 | 2 | 2 | 0 | 0 | 1 | 3 | 2.93 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 59 | 0 | 1 | 3 | 4.37 | .329 | 1.46 | 9.5 | 3.8 | 6.5 | 57.2 | 60 | 31 | 28 | 9 | 24 | 41 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 4.93 |
| RP | Howell, J.Howell, J.P. >> | 25 | 2008 | L | 34 | 57 | 0 | 1 | 5 | 5.14 | .331 | 1.45 | 8.0 | 5.0 | 9.5 | 56.0 | 50 | 35 | 32 | 6 | 31 | 59 | 0 | 5 | 2 | 0 | 0 | 2 | 4 | 4.05 |
| SP | Person, R.Person, Robert >> | 32 | 2001 | R | 24 | 38 | 0 | 1 | 3 | 6.87 | .381 | 1.83 | 12.7 | 3.9 | 6.8 | 56.1 | 79 | 45 | 43 | 17 | 24 | 42 | 0 | 7 | 2 | 0 | 0 | 1 | 0 | 6.79 |