| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 9 | 9 | 1 | 3 | 4.78 | .326 | 1.41 | 8.3 | 4.4 | 9.4 | 49.0 | 45 | 27 | 26 | 6 | 24 | 51 | 0 | 0 | 0 | 0 | 6 | 2 | 1 | 4.10 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 34 | 5 | 5 | 1 | 0 | 4.40 | .372 | 1.74 | 11.3 | 4.8 | 6.8 | 28.2 | 35 | 14 | 14 | 2 | 15 | 21 | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 4.14 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 49 | 9 | 8 | 4 | 2 | 3.77 | .286 | 1.13 | 8.5 | 1.7 | 6.9 | 57.1 | 54 | 25 | 24 | 9 | 11 | 44 | 0 | 0 | 0 | 0 | 5 | 4 | 2 | 4.30 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 71 | 7 | 7 | 2 | 3 | 4.70 | .320 | 1.34 | 6.5 | 5.5 | 6.5 | 44.0 | 32 | 23 | 23 | 6 | 27 | 32 | 0 | 0 | 0 | 0 | 3 | 3 | 2 | 5.36 |
| CL | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 18 | 0 | 0 | 3 | 3.78 | .383 | 1.86 | 8.4 | 9.0 | 6.8 | 16.2 | 15 | 7 | 7 | 1 | 16 | 12 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 5.31 |
| SU | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 50 | 10 | 0 | 2 | 1 | 4.09 | .313 | 1.27 | 5.7 | 5.7 | 4.9 | 11.0 | 7 | 5 | 5 | 2 | 7 | 6 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 6.45 |
| RP | Kim, B.Kim, Byung-Hyun >> | 23 | 2002 | R | 35 | 14 | 0 | 0 | 1 | 3.52 | .270 | 1.11 | 7.2 | 3.0 | 13.8 | 15.1 | 12 | 6 | 6 | 4 | 5 | 23 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.40 |
| RP | Ziegler, B.Ziegler, Brad + >> | 29 | 2008 | R | 13 | 17 | 0 | 1 | 0 | 2.66 | .265 | 1.08 | 6.8 | 3.2 | 7.2 | 20.1 | 15 | 8 | 6 | 3 | 7 | 16 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.40 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 76 | 14 | 0 | 1 | 0 | 4.24 | .301 | 1.29 | 5.8 | 5.8 | 12.2 | 17.0 | 11 | 8 | 8 | 2 | 11 | 23 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.76 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 11 | 0 | 0 | 3 | 6.17 | .327 | 1.37 | 9.8 | 3.3 | 7.4 | 11.2 | 12 | 9 | 8 | 4 | 4 | 9 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 7.45 |