| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 6 | 6 | 2 | 4 | 5.50 | .331 | 1.46 | 11.4 | 1.9 | 5.8 | 34.1 | 43 | 24 | 21 | 5 | 7 | 22 | 0 | 0 | 0 | 0 | 3 | 1 | 2 | 4.32 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 6 | 6 | 3 | 1 | 3.00 | .329 | 1.42 | 9.3 | 3.5 | 7.3 | 36.0 | 37 | 17 | 12 | 5 | 14 | 29 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 4.53 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 87 | 6 | 6 | 5 | 0 | 3.79 | .284 | 1.14 | 7.7 | 2.7 | 8.8 | 40.1 | 34 | 17 | 17 | 4 | 12 | 39 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 3.40 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 6 | 6 | 2 | 3 | 5.18 | .317 | 1.39 | 9.5 | 3.0 | 6.5 | 33.0 | 35 | 19 | 19 | 9 | 11 | 24 | 0 | 0 | 0 | 0 | 3 | 0 | 3 | 6.09 |
| SP | Clement, M.Clement, Matt >> | 28 | 2002 | R | 54 | 5 | 5 | 2 | 2 | 5.79 | .402 | 2.01 | 10.6 | 7.8 | 9.4 | 23.1 | 27 | 15 | 15 | 2 | 20 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.65 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 21 | 0 | 0 | 1 | 2.51 | .239 | 0.91 | 6.8 | 1.6 | 7.4 | 28.2 | 21 | 8 | 8 | 2 | 5 | 23 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 2.93 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 69 | 15 | 0 | 2 | 0 | 1.17 | .246 | 0.98 | 5.4 | 3.6 | 12.6 | 15.1 | 9 | 3 | 2 | 0 | 6 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.40 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 78 | 10 | 0 | 1 | 0 | 1.76 | .220 | 0.85 | 5.4 | 2.4 | 10.2 | 15.1 | 9 | 3 | 3 | 1 | 4 | 17 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.40 |