| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 20 | 20 | 9 | 5 | 3.06 | .272 | 1.09 | 7.2 | 2.6 | 9.5 | 159.0 | 127 | 64 | 54 | 19 | 46 | 168 | 6 | 0 | 0 | 1 | 14 | 5 | 5 | 3.40 |
| SP | Adams, B.Adams, Babe † >> | 27 | 1909 | R | 87 | 19 | 19 | 10 | 2 | 1.68 | .231 | 0.88 | 6.2 | 1.8 | 4.8 | 123.1 | 85 | 24 | 23 | 7 | 24 | 65 | 0 | 0 | 0 | 0 | 16 | 2 | 0 | 3.32 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 18 | 18 | 7 | 8 | 4.49 | .271 | 1.10 | 8.0 | 2.0 | 8.0 | 130.1 | 115 | 65 | 65 | 29 | 29 | 115 | 3 | 0 | 0 | 1 | 10 | 1 | 1 | 4.82 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 18 | 18 | 5 | 11 | 5.33 | .346 | 1.56 | 9.6 | 4.5 | 4.4 | 126.2 | 135 | 76 | 75 | 19 | 63 | 61 | 7 | 0 | 0 | 0 | 7 | 3 | 1 | 5.56 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 18 | 18 | 6 | 10 | 4.85 | .324 | 1.42 | 8.2 | 4.6 | 6.2 | 124.1 | 113 | 68 | 67 | 17 | 63 | 86 | 1 | 0 | 0 | 0 | 9 | 3 | 1 | 4.99 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 50 | 0 | 3 | 5 | 2.57 | .248 | 0.96 | 7.0 | 1.8 | 8.3 | 66.2 | 51 | 20 | 19 | 9 | 13 | 61 | 0 | 8 | 3 | 0 | 0 | 2 | 3 | 3.61 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 32 | 0 | 1 | 3 | 4.79 | .348 | 1.60 | 9.3 | 5.4 | 6.2 | 35.2 | 36 | 19 | 19 | 3 | 21 | 24 | 0 | 4 | 4 | 0 | 0 | 0 | 3 | 4.54 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 27 | 0 | 2 | 2 | 4.34 | .331 | 1.45 | 6.5 | 6.5 | 9.6 | 29.0 | 21 | 16 | 14 | 4 | 21 | 31 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.93 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 61 | 18 | 0 | 1 | 1 | 3.31 | .300 | 1.16 | 5.6 | 5.1 | 10.7 | 16.1 | 10 | 8 | 6 | 0 | 9 | 19 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 2.69 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 6 | 0 | 1 | 0 | 4.32 | .359 | 1.68 | 10.1 | 5.6 | 1.1 | 8.1 | 9 | 4 | 4 | 1 | 5 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.25 |