| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 20 | 20 | 8 | 3 | 3.41 | .293 | 1.21 | 8.5 | 2.4 | 8.9 | 124.0 | 117 | 47 | 47 | 10 | 33 | 123 | 2 | 0 | 0 | 2 | 13 | 4 | 0 | 2.96 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 18 | 18 | 7 | 6 | 6.09 | .340 | 1.54 | 11.2 | 2.6 | 8.8 | 99.0 | 123 | 71 | 67 | 21 | 29 | 97 | 3 | 0 | 0 | 0 | 7 | 1 | 1 | 4.71 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 17 | 17 | 5 | 3 | 5.47 | .339 | 1.49 | 10.0 | 3.4 | 6.1 | 97.0 | 108 | 65 | 59 | 22 | 37 | 66 | 1 | 0 | 0 | 0 | 7 | 4 | 1 | 5.86 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 21 | 18 | 8 | 4 | 5.05 | .314 | 1.35 | 8.8 | 3.4 | 4.2 | 112.1 | 110 | 66 | 63 | 15 | 42 | 52 | 3 | 0 | 0 | 1 | 7 | 2 | 5 | 4.99 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 52 | 0 | 3 | 9 | 3.39 | .271 | 1.10 | 6.6 | 3.2 | 9.0 | 61.0 | 45 | 23 | 23 | 8 | 22 | 61 | 0 | 19 | 2 | 0 | 0 | 1 | 1 | 3.84 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 51 | 0 | 0 | 2 | 3.29 | .296 | 1.24 | 7.2 | 4.2 | 9.7 | 54.2 | 43 | 21 | 20 | 6 | 25 | 58 | 0 | 2 | 5 | 0 | 0 | 1 | 0 | 3.74 |