| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 20 | 20 | 10 | 7 | 3.07 | .256 | 1.02 | 7.0 | 2.3 | 8.1 | 164.0 | 127 | 61 | 56 | 15 | 41 | 148 | 9 | 0 | 0 | 2 | 15 | 1 | 3 | 3.15 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 89 | 20 | 19 | 8 | 6 | 3.32 | .293 | 1.23 | 8.3 | 2.8 | 4.6 | 149.0 | 137 | 63 | 55 | 14 | 46 | 76 | 9 | 0 | 0 | 4 | 10 | 2 | 5 | 4.17 |
| SP | Maddux, G.Maddux, Greg $$ >> | 29 | 1995 | R | 89 | 19 | 19 | 12 | 6 | 2.99 | .257 | 1.01 | 7.5 | 1.6 | 4.3 | 159.1 | 133 | 59 | 53 | 19 | 28 | 76 | 15 | 0 | 0 | 2 | 12 | 4 | 0 | 4.20 |
| SP | Snell, B.Snell, Blake $ >> | 25 | 2018 | L | 81 | 18 | 18 | 5 | 7 | 3.45 | .277 | 1.14 | 6.7 | 3.6 | 7.3 | 114.2 | 85 | 46 | 44 | 13 | 46 | 93 | 0 | 0 | 0 | 0 | 11 | 1 | 1 | 4.09 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 16 | 16 | 4 | 6 | 3.33 | .306 | 1.32 | 7.0 | 4.9 | 7.7 | 97.1 | 75 | 36 | 36 | 11 | 53 | 83 | 0 | 0 | 0 | 0 | 9 | 1 | 4 | 4.43 |
| RP | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 43 | 0 | 7 | 2 | 2.80 | .187 | 0.69 | 4.0 | 2.2 | 9.2 | 45.0 | 20 | 14 | 14 | 4 | 11 | 46 | 0 | 1 | 2 | 0 | 0 | 0 | 2 | 2.84 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 23 | 0 | 6 | 1 | 2.28 | .330 | 1.48 | 5.9 | 7.8 | 9.0 | 23.2 | 15 | 6 | 6 | 4 | 20 | 23 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 5.87 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 58 | 18 | 0 | 1 | 0 | 0.44 | .151 | 0.53 | 1.4 | 3.6 | 9.9 | 20.2 | 3 | 1 | 1 | 0 | 8 | 22 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 2.00 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 14 | 0 | 2 | 1 | 2.08 | .264 | 1.08 | 7.6 | 2.1 | 5.5 | 26.0 | 22 | 8 | 6 | 1 | 6 | 16 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.96 |
| SP | Fernandez, S.Fernandez, Sid $ >> | 23 | 1985 | L | 49 | 3 | 1 | 0 | 1 | 6.75 | .394 | 1.88 | 11.8 | 5.5 | 9.0 | 13.1 | 17 | 10 | 10 | 3 | 8 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 6.08 |