| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 34 | 34 | 22 | 7 | 2.95 | .274 | 1.11 | 8.0 | 2.0 | 10.6 | 238.0 | 212 | 81 | 78 | 28 | 52 | 279 | 2 | 0 | 0 | 1 | 28 | 6 | 5 | 2.92 |
| SP | Gilbert, L.Gilbert, Logan >> | 28 | 2025 | R | 91 | 34 | 34 | 12 | 7 | 4.90 | .339 | 1.51 | 10.5 | 3.1 | 10.0 | 178.0 | 207 | 98 | 97 | 34 | 62 | 198 | 0 | 0 | 0 | 0 | 8 | 5 | 8 | 4.39 |
| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 88 | 32 | 32 | 10 | 6 | 2.62 | .281 | 1.14 | 6.2 | 4.1 | 10.3 | 178.1 | 122 | 56 | 52 | 10 | 82 | 203 | 0 | 0 | 0 | 0 | 11 | 5 | 10 | 2.92 |
| SP | Horton, C.Horton, Cade >> | 23 | 2025 | R | 80 | 32 | 32 | 17 | 8 | 3.62 | .310 | 1.31 | 8.5 | 3.3 | 6.5 | 176.2 | 167 | 79 | 71 | 21 | 65 | 128 | 0 | 0 | 0 | 0 | 14 | 6 | 0 | 4.31 |
| SP | Kelly, M.Kelly, Merrill # >> | 36 | 2025 | R | 72 | 31 | 30 | 14 | 6 | 3.51 | .288 | 1.18 | 8.0 | 2.6 | 8.4 | 197.1 | 176 | 79 | 77 | 18 | 56 | 184 | 0 | 0 | 0 | 0 | 14 | 8 | 3 | 3.29 |
| RP | Miller, M.Miller, Mason >> | 26 | 2025 | R | 99 | 88 | 0 | 6 | 6 | 3.21 | .260 | 1.05 | 5.2 | 4.3 | 10.9 | 123.1 | 71 | 46 | 44 | 12 | 59 | 149 | 0 | 5 | 2 | 0 | 0 | 0 | 1 | 3.28 |
| RP | Keller, B.Keller, Brad >> | 29 | 2025 | R | 89 | 88 | 0 | 5 | 9 | 3.57 | .297 | 1.23 | 7.2 | 3.9 | 8.9 | 116.0 | 93 | 47 | 46 | 14 | 50 | 115 | 0 | 8 | 6 | 0 | 0 | 4 | 1 | 3.98 |
| RP | Bautista, F.Bautista, Félix >> | 30 | 2025 | R | 85 | 78 | 0 | 4 | 4 | 3.27 | .330 | 1.45 | 5.9 | 7.2 | 11.1 | 88.0 | 58 | 34 | 32 | 8 | 70 | 109 | 0 | 10 | 6 | 0 | 0 | 2 | 2 | 4.16 |
| RP | Sousa, B.Sousa, Bennett >> | 30 | 2025 | L | 80 | 63 | 0 | 6 | 1 | 3.41 | .301 | 1.23 | 7.0 | 4.2 | 8.9 | 71.1 | 55 | 28 | 27 | 6 | 33 | 70 | 0 | 8 | 3 | 0 | 0 | 4 | 3 | 3.69 |
| RP | Henriquez, R.Henriquez, Ronny # >> | 25 | 2025 | R | 77 | 48 | 0 | 4 | 5 | 5.47 | .360 | 1.65 | 9.4 | 5.5 | 10.2 | 51.0 | 53 | 31 | 31 | 7 | 31 | 58 | 0 | 8 | 3 | 0 | 0 | 2 | 1 | 4.45 |
| RP | Fairbanks, P.Fairbanks, Peter >> | 31 | 2025 | R | 74 | 41 | 0 | 2 | 1 | 2.23 | .296 | 1.24 | 9.0 | 2.3 | 8.2 | 44.1 | 44 | 11 | 11 | 5 | 11 | 40 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 3.48 |