| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 16 | 16 | 5 | 5 | 3.12 | .275 | 1.13 | 8.0 | 2.2 | 10.5 | 112.2 | 100 | 40 | 39 | 10 | 27 | 131 | 1 | 0 | 0 | 1 | 8 | 1 | 2 | 2.57 |
| SP | Gilbert, L.Gilbert, Logan # >> | 28 | 2025 | R | 91 | 16 | 16 | 6 | 4 | 4.38 | .314 | 1.35 | 9.7 | 2.5 | 10.8 | 90.1 | 97 | 45 | 44 | 16 | 25 | 108 | 0 | 0 | 0 | 0 | 6 | 2 | 5 | 3.81 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 81 | 16 | 16 | 7 | 4 | 2.66 | .270 | 1.07 | 6.2 | 3.5 | 8.6 | 101.2 | 70 | 31 | 30 | 12 | 39 | 97 | 0 | 0 | 0 | 0 | 12 | 4 | 1 | 3.90 |
| SP | Lodolo, N.Lodolo, Nick >> | 27 | 2025 | L | 78 | 16 | 16 | 7 | 5 | 5.20 | .345 | 1.53 | 11.2 | 2.6 | 9.8 | 83.0 | 103 | 53 | 48 | 18 | 24 | 90 | 0 | 0 | 0 | 0 | 5 | 4 | 4 | 4.66 |
| RP | Miller, M.Miller, Mason >> | 26 | 2025 | R | 99 | 40 | 0 | 4 | 2 | 2.31 | .274 | 1.08 | 5.9 | 3.9 | 12.6 | 58.1 | 38 | 15 | 15 | 2 | 25 | 81 | 0 | 0 | 1 | 0 | 0 | 3 | 3 | 2.10 |
| RP | Santana, D.Santana, Dennis >> | 29 | 2025 | R | 92 | 43 | 0 | 3 | 2 | 3.49 | .261 | 1.06 | 6.4 | 3.2 | 7.8 | 59.1 | 42 | 23 | 23 | 9 | 21 | 51 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 4.32 |
| RP | Kittredge, A.Kittredge, Andrew >> | 35 | 2025 | R | 84 | 39 | 0 | 1 | 3 | 6.13 | .319 | 1.40 | 9.6 | 3.1 | 9.4 | 47.0 | 50 | 32 | 32 | 7 | 16 | 49 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 3.87 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 78 | 33 | 0 | 7 | 2 | 4.34 | .313 | 1.31 | 8.0 | 3.9 | 6.6 | 37.1 | 33 | 21 | 18 | 6 | 16 | 27 | 0 | 5 | 5 | 0 | 0 | 2 | 3 | 5.11 |
| RP | Rodríguez, Y.Rodríguez, Yariel >> | 28 | 2025 | R | 68 | 29 | 0 | 2 | 1 | 4.26 | .354 | 1.61 | 7.5 | 7.3 | 10.2 | 31.2 | 26 | 17 | 15 | 1 | 25 | 35 | 0 | 4 | 1 | 0 | 0 | 1 | 2 | 3.68 |
| RP | Pomeranz, D.Pomeranz, Drew >> | 36 | 2025 | L | 72 | 19 | 0 | 0 | 0 | 2.05 | .290 | 1.23 | 7.4 | 3.7 | 9.0 | 22.0 | 18 | 7 | 5 | 1 | 9 | 22 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 2.82 |
| SP | Kirby, G.Kirby, George >> | 27 | 2025 | R | 66 | 8 | 0 | 3 | 2 | 4.09 | .377 | 1.82 | 13.1 | 3.3 | 13.1 | 11.0 | 16 | 5 | 5 | 1 | 4 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.36 |