| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 23 | 23 | 5 | 15 | 6.52 | .354 | 1.65 | 11.3 | 3.5 | 5.7 | 146.1 | 184 | 108 | 106 | 26 | 57 | 92 | 5 | 0 | 0 | 0 | 7 | 0 | 2 | 5.23 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 22 | 22 | 8 | 10 | 5.84 | .338 | 1.48 | 10.0 | 3.4 | 3.7 | 138.2 | 153 | 94 | 90 | 19 | 52 | 56 | 4 | 0 | 0 | 1 | 8 | 7 | 4 | 5.26 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 22 | 22 | 6 | 11 | 5.28 | .341 | 1.52 | 10.3 | 3.5 | 5.1 | 151.2 | 173 | 89 | 89 | 21 | 58 | 86 | 6 | 0 | 0 | 0 | 6 | 4 | 2 | 4.90 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 22 | 22 | 4 | 9 | 5.23 | .342 | 1.53 | 10.1 | 3.6 | 5.9 | 134.1 | 151 | 87 | 78 | 14 | 54 | 88 | 1 | 0 | 0 | 0 | 7 | 4 | 3 | 4.34 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 56 | 0 | 7 | 0 | 2.87 | .292 | 1.22 | 8.3 | 2.8 | 9.7 | 75.1 | 69 | 28 | 24 | 12 | 23 | 81 | 0 | 3 | 1 | 0 | 0 | 1 | 2 | 3.88 |
| RP | Benitez, A.Benitez, Armando † >> | 32 | 2004 | R | 81 | 51 | 0 | 4 | 0 | 2.92 | .283 | 1.18 | 6.6 | 4.1 | 6.0 | 61.2 | 45 | 22 | 20 | 3 | 28 | 41 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3.67 |
| RP | Clippard, T.Clippard, Tyler # >> | 26 | 2011 | R | 79 | 43 | 0 | 4 | 4 | 6.31 | .348 | 1.58 | 9.4 | 5.0 | 8.0 | 45.2 | 47 | 32 | 32 | 6 | 25 | 40 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 4.69 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 35 | 0 | 1 | 2 | 4.28 | .298 | 1.28 | 10.1 | 1.4 | 7.2 | 40.0 | 45 | 22 | 19 | 6 | 6 | 32 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 3.80 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 75 | 29 | 0 | 2 | 0 | 5.61 | .313 | 1.37 | 9.5 | 3.0 | 9.3 | 33.2 | 35 | 22 | 21 | 10 | 11 | 34 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 5.88 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 5 | 0 | 0 | 0 | 3.38 | .467 | 2.63 | 31.5 | 0.0 | 18.0 | 2.2 | 7 | 1 | 1 | 1 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.50 |