| SP | Martinez, P.Martinez, Pedro # >> | 29 | 2000 | R | 100 | 23 | 23 | 9 | 9 | 4.35 | .298 | 1.23 | 8.2 | 2.9 | 9.2 | 161.1 | 147 | 92 | 78 | 25 | 52 | 164 | 3 | 0 | 0 | 1 | 13 | 6 | 3 | 4.06 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 21 | 21 | 6 | 11 | 4.21 | .297 | 1.26 | 8.8 | 2.5 | 6.3 | 154.0 | 151 | 77 | 72 | 17 | 43 | 108 | 6 | 0 | 0 | 0 | 13 | 1 | 3 | 3.89 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 21 | 21 | 5 | 12 | 5.32 | .338 | 1.50 | 9.9 | 3.7 | 5.7 | 143.2 | 157 | 94 | 85 | 26 | 59 | 90 | 3 | 0 | 0 | 0 | 7 | 4 | 2 | 5.43 |
| SP | Chesbro, J.Chesbro, Jack † >> | 30 | 1904 | R | 65 | 21 | 21 | 14 | 6 | 3.95 | .302 | 1.29 | 8.5 | 3.1 | 3.5 | 171.0 | 161 | 82 | 75 | 19 | 59 | 67 | 12 | 0 | 0 | 2 | 12 | 2 | 3 | 4.73 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 56 | 0 | 2 | 3 | 4.03 | .297 | 1.25 | 7.5 | 3.8 | 8.2 | 67.0 | 56 | 30 | 30 | 9 | 28 | 61 | 0 | 9 | 5 | 0 | 0 | 1 | 0 | 4.22 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 38 | 0 | 2 | 0 | 2.40 | .281 | 1.17 | 6.8 | 3.9 | 9.0 | 48.2 | 36 | 13 | 13 | 2 | 21 | 48 | 0 | 6 | 2 | 0 | 0 | 0 | 1 | 2.85 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 16 | 0 | 4 | 0 | 5.87 | .395 | 1.96 | 12.0 | 6.0 | 10.2 | 15.1 | 20 | 10 | 10 | 3 | 10 | 17 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.33 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 14 | 0 | 1 | 1 | 7.82 | .397 | 1.82 | 12.8 | 4.5 | 7.5 | 12.2 | 17 | 12 | 11 | 2 | 6 | 10 | 0 | 2 | 0 | 0 | 0 | 2 | 2 | 5.50 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 54 | 17 | 0 | 0 | 0 | 2.96 | .270 | 1.11 | 6.4 | 3.8 | 10.5 | 24.1 | 17 | 8 | 8 | 2 | 10 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.00 |
| SP | Overall, O.Overall, Orval >> | 28 | 1909 | R | 57 | 2 | 1 | 1 | 0 | 5.40 | .333 | 1.30 | 9.0 | 2.7 | 8.1 | 10.0 | 10 | 6 | 6 | 0 | 3 | 9 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 2.70 |