| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 24 | 24 | 8 | 8 | 4.06 | .276 | 1.12 | 8.1 | 2.0 | 8.7 | 162.0 | 146 | 76 | 73 | 17 | 36 | 156 | 0 | 0 | 0 | 0 | 14 | 3 | 0 | 3.16 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 22 | 22 | 5 | 14 | 4.23 | .341 | 1.52 | 10.3 | 3.4 | 5.6 | 155.1 | 178 | 84 | 73 | 13 | 58 | 96 | 4 | 0 | 0 | 1 | 10 | 5 | 4 | 4.07 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 71 | 22 | 22 | 7 | 10 | 5.76 | .351 | 1.62 | 10.7 | 3.8 | 5.4 | 125.0 | 149 | 89 | 80 | 23 | 53 | 75 | 0 | 0 | 0 | 0 | 9 | 1 | 1 | 5.49 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 22 | 22 | 4 | 12 | 5.46 | .343 | 1.55 | 11.0 | 3.0 | 5.0 | 148.1 | 181 | 100 | 90 | 20 | 49 | 82 | 1 | 0 | 0 | 0 | 9 | 2 | 2 | 4.68 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 58 | 0 | 4 | 4 | 4.52 | .323 | 1.42 | 8.0 | 4.8 | 8.7 | 65.2 | 58 | 34 | 33 | 10 | 35 | 63 | 0 | 4 | 5 | 0 | 0 | 1 | 0 | 4.72 |
| RP | Saito, T.Saito, Takashi # >> | 37 | 2007 | R | 91 | 50 | 0 | 2 | 4 | 6.15 | .350 | 1.56 | 9.5 | 4.7 | 8.1 | 52.2 | 55 | 36 | 36 | 8 | 27 | 47 | 0 | 5 | 0 | 0 | 0 | 3 | 0 | 4.92 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 26 | 0 | 2 | 1 | 5.67 | .331 | 1.44 | 7.0 | 6.0 | 8.0 | 27.0 | 21 | 21 | 17 | 7 | 18 | 24 | 0 | 3 | 2 | 0 | 0 | 1 | 1 | 6.70 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 15 | 0 | 2 | 0 | 3.00 | .300 | 1.29 | 8.1 | 3.4 | 7.3 | 21.0 | 19 | 7 | 7 | 4 | 8 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.00 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 60 | 18 | 0 | 0 | 1 | 1.04 | .235 | 0.92 | 6.6 | 1.7 | 6.2 | 26.0 | 19 | 3 | 3 | 2 | 5 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.19 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 5 | 0 | 0 | 1 | 17.36 | .481 | 2.79 | 15.8 | 13.5 | 15.8 | 4.2 | 7 | 9 | 9 | 1 | 6 | 7 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 7.25 |