| SP | Koufax, S.Koufax, Sandy $$ >> | 30 | 1965 | L | 97 | 33 | 33 | 15 | 10 | 3.68 | .279 | 1.13 | 7.8 | 2.4 | 8.5 | 247.1 | 214 | 106 | 101 | 23 | 66 | 234 | 5 | 0 | 0 | 2 | 18 | 7 | 4 | 3.20 |
| SP | Maddux, G.Maddux, Greg $ >> | 29 | 1995 | R | 89 | 32 | 32 | 14 | 13 | 4.00 | .285 | 1.17 | 7.9 | 2.7 | 5.9 | 245.1 | 215 | 112 | 109 | 19 | 73 | 160 | 13 | 0 | 0 | 1 | 16 | 6 | 5 | 3.67 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 31 | 31 | 7 | 8 | 3.48 | .287 | 1.18 | 7.6 | 3.1 | 7.4 | 165.2 | 139 | 69 | 64 | 16 | 56 | 136 | 0 | 0 | 0 | 0 | 9 | 5 | 2 | 3.72 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 30 | 30 | 11 | 11 | 4.99 | .316 | 1.36 | 10.1 | 2.2 | 4.7 | 211.0 | 236 | 118 | 117 | 34 | 51 | 110 | 4 | 0 | 0 | 1 | 13 | 5 | 2 | 4.85 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 82 | 0 | 3 | 3 | 1.99 | .226 | 0.86 | 6.6 | 1.2 | 7.5 | 108.2 | 79 | 26 | 24 | 8 | 14 | 90 | 0 | 10 | 4 | 0 | 0 | 2 | 0 | 2.74 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 65 | 0 | 3 | 7 | 3.06 | .260 | 1.01 | 7.4 | 1.7 | 9.1 | 85.1 | 70 | 29 | 29 | 4 | 16 | 86 | 0 | 11 | 4 | 0 | 0 | 4 | 1 | 2.29 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 47 | 0 | 6 | 7 | 2.77 | .242 | 0.96 | 6.5 | 2.1 | 9.3 | 55.1 | 40 | 17 | 17 | 3 | 13 | 57 | 0 | 6 | 2 | 0 | 0 | 0 | 2 | 2.35 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 28 | 0 | 2 | 3 | 2.61 | .268 | 1.10 | 7.0 | 2.9 | 8.1 | 31.0 | 24 | 9 | 9 | 2 | 10 | 28 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 23 | 0 | 3 | 1 | 4.71 | .312 | 1.36 | 8.4 | 4.2 | 8.4 | 28.2 | 26 | 15 | 15 | 4 | 13 | 26 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4.39 |