| SP | Perez, O.Perez, Oliver >> | 23 | 2004 | L | 76 | 20 | 20 | 10 | 4 | 3.54 | .305 | 1.28 | 6.7 | 4.9 | 9.4 | 124.2 | 92 | 50 | 49 | 16 | 67 | 129 | 1 | 0 | 0 | 0 | 13 | 5 | 1 | 4.34 |
| SP | Harden, R.Harden, Rich † >> | 27 | 2008 | R | 95 | 21 | 21 | 9 | 3 | 3.39 | .291 | 1.19 | 6.9 | 3.8 | 9.2 | 109.0 | 84 | 41 | 41 | 12 | 46 | 111 | 0 | 0 | 0 | 0 | 8 | 4 | 2 | 3.77 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 86 | 20 | 20 | 7 | 8 | 4.15 | .306 | 1.27 | 8.6 | 2.7 | 7.2 | 128.0 | 123 | 63 | 59 | 11 | 39 | 102 | 3 | 0 | 0 | 2 | 11 | 7 | 3 | 3.60 |
| SP | Webb, B.Webb, Brandon # >> | 24 | 2003 | R | 64 | 20 | 20 | 6 | 7 | 5.38 | .306 | 1.30 | 8.8 | 3.0 | 8.0 | 112.0 | 109 | 68 | 67 | 28 | 37 | 99 | 0 | 0 | 0 | 0 | 8 | 2 | 4 | 5.53 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 77 | 20 | 20 | 6 | 8 | 5.21 | .324 | 1.43 | 9.7 | 3.2 | 8.3 | 114.0 | 123 | 77 | 66 | 24 | 40 | 105 | 0 | 0 | 0 | 0 | 9 | 1 | 0 | 4.97 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 34 | 0 | 5 | 2 | 6.42 | .384 | 1.81 | 8.2 | 8.5 | 7.6 | 33.2 | 30 | 25 | 24 | 5 | 31 | 28 | 0 | 1 | 2 | 0 | 0 | 2 | 2 | 6.27 |
| RP | Otsuka, A.Otsuka, Akinori >> | 32 | 2004 | R | 44 | 21 | 0 | 1 | 0 | 2.79 | .293 | 1.24 | 7.6 | 3.8 | 6.6 | 19.1 | 16 | 6 | 6 | 1 | 8 | 14 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.47 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 31 | 0 | 1 | 1 | 3.79 | .297 | 1.24 | 7.9 | 3.4 | 9.0 | 40.1 | 35 | 17 | 17 | 2 | 15 | 40 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 2.85 |
| CL | Neshek, P.Neshek, Pat † $ >> | 26 | 2006 | R | 94 | 37 | 0 | 1 | 3 | 4.24 | .333 | 1.47 | 9.8 | 3.4 | 10.6 | 34.0 | 37 | 16 | 16 | 4 | 13 | 40 | 0 | 26 | 4 | 0 | 0 | 1 | 0 | 3.41 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 13 | 0 | 3 | 1 | 5.40 | .345 | 1.53 | 12.3 | 1.8 | 5.8 | 36.2 | 49 | 26 | 22 | 10 | 7 | 23 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 6.08 |