| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 28 | 28 | 7 | 8 | 3.52 | .278 | 1.14 | 7.7 | 2.5 | 9.3 | 135.1 | 116 | 58 | 53 | 13 | 38 | 139 | 0 | 0 | 0 | 0 | 3 | 2 | 5 | 3.08 |
| SP | Duchscherer, J.Duchscherer, Justin † >> | 31 | 2008 | R | 85 | 27 | 27 | 14 | 9 | 2.70 | .268 | 1.05 | 6.9 | 2.6 | 6.1 | 197.0 | 150 | 60 | 59 | 15 | 56 | 134 | 1 | 0 | 0 | 0 | 23 | 10 | 1 | 3.63 |
| SP | Loaiza, E.Loaiza, Esteban >> | 32 | 2003 | R | 61 | 27 | 27 | 5 | 12 | 5.70 | .341 | 1.50 | 10.7 | 2.9 | 7.4 | 167.1 | 198 | 110 | 106 | 28 | 53 | 138 | 0 | 0 | 0 | 0 | 10 | 9 | 3 | 4.64 |
| SP | Burnett, A.Burnett, A.J. # >> | 25 | 2002 | R | 56 | 27 | 27 | 10 | 9 | 5.01 | .320 | 1.40 | 9.1 | 3.5 | 8.5 | 170.2 | 172 | 95 | 95 | 27 | 67 | 161 | 1 | 0 | 0 | 1 | 11 | 2 | 11 | 4.39 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 76 | 0 | 6 | 2 | 4.43 | .299 | 1.22 | 7.8 | 3.2 | 7.7 | 109.2 | 95 | 56 | 54 | 17 | 39 | 93 | 0 | 4 | 5 | 0 | 0 | 6 | 2 | 4.56 |
| RP | Zimmerman, J.Zimmerman, Jeff # >> | 29 | 2001 | R | 75 | 67 | 0 | 5 | 3 | 4.47 | .308 | 1.29 | 9.1 | 2.6 | 8.4 | 90.2 | 91 | 48 | 45 | 14 | 26 | 84 | 0 | 7 | 2 | 0 | 0 | 4 | 0 | 4.16 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 50 | 62 | 0 | 6 | 5 | 3.81 | .295 | 1.20 | 6.1 | 4.7 | 8.9 | 80.1 | 54 | 35 | 34 | 6 | 42 | 79 | 0 | 7 | 2 | 0 | 0 | 5 | 8 | 3.76 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 32 | 2004 | R | 37 | 48 | 0 | 5 | 5 | 3.51 | .306 | 1.25 | 7.8 | 3.5 | 9.3 | 59.0 | 51 | 23 | 23 | 6 | 23 | 61 | 0 | 10 | 1 | 0 | 0 | 4 | 1 | 3.63 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 44 | 4 | 0 | 1 | 0 | 5.63 | .333 | 1.50 | 11.3 | 2.3 | 15.8 | 8.0 | 10 | 5 | 5 | 2 | 2 | 14 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.50 |
| SP | Willis, D.Willis, Dontrelle >> | 23 | 2005 | L | 50 | 29 | 0 | 3 | 3 | 4.58 | .329 | 1.47 | 9.8 | 3.4 | 6.1 | 53.0 | 58 | 27 | 27 | 5 | 20 | 36 | 0 | 7 | 1 | 0 | 0 | 0 | 1 | 4.00 |