| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 15 | 15 | 3 | 5 | 5.21 | .331 | 1.44 | 9.9 | 3.1 | 8.7 | 67.1 | 74 | 40 | 39 | 14 | 23 | 65 | 0 | 0 | 0 | 0 | 1 | 3 | 3 | 4.94 |
| SP | Duchscherer, J.Duchscherer, Justin # >> | 31 | 2008 | R | 86 | 15 | 15 | 8 | 4 | 3.93 | .311 | 1.34 | 9.6 | 2.5 | 6.0 | 107.2 | 114 | 49 | 47 | 18 | 30 | 71 | 1 | 0 | 0 | 0 | 10 | 2 | 1 | 4.76 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 82 | 15 | 15 | 7 | 5 | 3.47 | .298 | 1.24 | 8.9 | 2.2 | 5.7 | 114.0 | 113 | 48 | 44 | 20 | 28 | 72 | 7 | 0 | 0 | 0 | 9 | 4 | 3 | 4.86 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 65 | 15 | 15 | 5 | 9 | 5.42 | .329 | 1.46 | 10.1 | 3.1 | 6.2 | 93.0 | 104 | 59 | 56 | 12 | 32 | 64 | 0 | 0 | 0 | 0 | 5 | 1 | 2 | 4.37 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 96 | 39 | 0 | 4 | 3 | 4.37 | .305 | 1.30 | 8.8 | 3.0 | 9.6 | 57.2 | 56 | 29 | 28 | 5 | 19 | 61 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 3.05 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 62 | 30 | 0 | 2 | 2 | 4.05 | .320 | 1.38 | 8.2 | 4.4 | 6.5 | 33.1 | 30 | 15 | 15 | 5 | 16 | 24 | 0 | 6 | 0 | 0 | 0 | 1 | 0 | 5.06 |
| RP | Mota, G.Mota, Guillermo >> | 30 | 2003 | R | 48 | 23 | 0 | 2 | 0 | 2.84 | .290 | 1.14 | 7.6 | 2.9 | 7.6 | 25.1 | 21 | 8 | 8 | 4 | 8 | 21 | 0 | 6 | 0 | 0 | 0 | 2 | 0 | 4.60 |
| RP | Donnelly, B.Donnelly, Brendan >> | 32 | 2003 | R | 37 | 16 | 0 | 0 | 0 | 3.66 | .263 | 1.02 | 6.6 | 2.8 | 6.6 | 19.2 | 14 | 8 | 8 | 2 | 6 | 14 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.00 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 50 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Johnson, J.Johnson, Josh >> | 25 | 2009 | R | 49 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Appier, K.Appier, Kevin >> | 34 | 2001 | R | 38 | 1 | 0 | 0 | 0 | 0.00 | .250 | 1.00 | 9.0 | 0.0 | 0.0 | 1.0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |