| SP | Martinez, P.Martinez, Pedro † $ >> | 29 | 2000 | R | 100 | 30 | 30 | 10 | 7 | 3.06 | .270 | 1.08 | 6.9 | 2.9 | 9.8 | 203.0 | 155 | 73 | 69 | 29 | 65 | 222 | 2 | 0 | 0 | 2 | 22 | 5 | 3 | 3.70 |
| SP | Peavy, J.Peavy, Jake † # >> | 26 | 2007 | R | 88 | 29 | 29 | 14 | 4 | 3.88 | .298 | 1.24 | 8.8 | 2.4 | 9.2 | 181.0 | 176 | 83 | 78 | 21 | 49 | 186 | 0 | 0 | 0 | 0 | 17 | 5 | 2 | 3.35 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 76 | 28 | 28 | 6 | 7 | 5.53 | .328 | 1.45 | 10.0 | 3.1 | 8.2 | 138.1 | 154 | 93 | 85 | 30 | 47 | 126 | 0 | 0 | 0 | 0 | 7 | 2 | 7 | 5.07 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 69 | 28 | 28 | 10 | 9 | 5.51 | .360 | 1.64 | 9.9 | 4.8 | 6.2 | 147.0 | 162 | 92 | 90 | 21 | 79 | 102 | 0 | 0 | 0 | 0 | 9 | 7 | 3 | 5.22 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 55 | 29 | 27 | 6 | 9 | 7.38 | .379 | 1.75 | 11.6 | 4.2 | 6.6 | 122.0 | 157 | 106 | 100 | 28 | 57 | 90 | 0 | 0 | 0 | 0 | 2 | 9 | 2 | 6.13 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 81 | 0 | 7 | 3 | 3.04 | .262 | 1.02 | 7.5 | 1.8 | 9.5 | 94.2 | 78 | 37 | 32 | 9 | 19 | 99 | 0 | 0 | 2 | 0 | 0 | 4 | 0 | 2.87 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 76 | 57 | 0 | 3 | 3 | 3.50 | .299 | 1.25 | 6.9 | 4.4 | 9.1 | 61.2 | 47 | 26 | 24 | 9 | 30 | 62 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 4.46 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 49 | 0 | 4 | 1 | 5.19 | .330 | 1.45 | 7.7 | 5.4 | 9.2 | 43.1 | 37 | 25 | 25 | 5 | 26 | 44 | 0 | 1 | 2 | 0 | 0 | 1 | 5 | 4.35 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 68 | 34 | 0 | 4 | 3 | 7.60 | .387 | 1.89 | 10.6 | 6.6 | 10.6 | 34.1 | 40 | 30 | 29 | 5 | 25 | 40 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.76 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 57 | 37 | 0 | 3 | 0 | 4.02 | .266 | 1.05 | 5.5 | 4.1 | 9.0 | 31.1 | 19 | 15 | 14 | 3 | 14 | 31 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.71 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 64 | 75 | 0 | 5 | 3 | 4.64 | .304 | 1.28 | 7.9 | 3.7 | 9.7 | 64.0 | 56 | 34 | 33 | 10 | 26 | 69 | 0 | 1 | 1 | 0 | 0 | 2 | 5 | 4.19 |
| RP | Guardado, E.Guardado, Eddie >> | 34 | 2004 | L | 54 | 60 | 0 | 1 | 1 | 7.11 | .364 | 1.69 | 9.4 | 5.9 | 8.8 | 44.1 | 46 | 35 | 35 | 8 | 29 | 43 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5.45 |
| CL | Nathan, J.Nathan, Joe † >> | 32 | 2006 | R | 98 | 54 | 0 | 4 | 11 | 4.31 | .335 | 1.44 | 8.8 | 4.2 | 10.0 | 54.1 | 53 | 27 | 26 | 7 | 25 | 60 | 0 | 32 | 6 | 0 | 0 | 4 | 3 | 4.07 |
| SU | Wagner, B.Wagner, Billy # >> | 33 | 2004 | L | 91 | 50 | 0 | 1 | 3 | 5.43 | .290 | 1.21 | 8.7 | 2.2 | 10.0 | 53.0 | 51 | 33 | 32 | 11 | 13 | 59 | 0 | 5 | 7 | 0 | 0 | 1 | 2 | 4.26 |