| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 21 | 21 | 10 | 9 | 4.66 | .301 | 1.27 | 9.7 | 1.8 | 9.1 | 150.2 | 162 | 79 | 78 | 23 | 30 | 151 | 5 | 0 | 0 | 2 | 8 | 3 | 3 | 3.64 |
| SP | Vazquez, J.Vazquez, Javier # >> | 33 | 2009 | R | 87 | 21 | 21 | 11 | 7 | 4.99 | .323 | 1.37 | 9.7 | 2.6 | 8.5 | 137.0 | 148 | 79 | 76 | 22 | 40 | 130 | 1 | 0 | 0 | 0 | 9 | 8 | 2 | 4.24 |
| SP | Perez, O.Perez, Odalis † >> | 25 | 2002 | L | 82 | 20 | 20 | 12 | 6 | 4.03 | .311 | 1.30 | 9.3 | 2.5 | 6.1 | 131.2 | 135 | 62 | 59 | 11 | 36 | 89 | 4 | 0 | 0 | 2 | 10 | 7 | 2 | 3.72 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 73 | 20 | 20 | 8 | 9 | 5.46 | .325 | 1.40 | 9.9 | 2.7 | 7.6 | 112.0 | 123 | 75 | 68 | 19 | 34 | 95 | 1 | 0 | 0 | 1 | 9 | 5 | 0 | 4.55 |
| SP | Loaiza, E.Loaiza, Esteban >> | 32 | 2003 | R | 60 | 20 | 13 | 4 | 5 | 6.30 | .350 | 1.59 | 11.1 | 3.2 | 7.0 | 84.1 | 104 | 65 | 59 | 11 | 30 | 65 | 0 | 1 | 0 | 0 | 3 | 2 | 3 | 4.30 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 54 | 0 | 1 | 1 | 3.83 | .314 | 1.34 | 9.2 | 3.0 | 11.3 | 51.2 | 52 | 22 | 22 | 8 | 17 | 64 | 0 | 5 | 2 | 0 | 0 | 2 | 0 | 3.65 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 86 | 43 | 0 | 1 | 3 | 3.23 | .268 | 1.10 | 6.1 | 3.8 | 8.4 | 47.1 | 32 | 18 | 17 | 6 | 20 | 44 | 0 | 7 | 1 | 0 | 0 | 0 | 3 | 4.06 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 73 | 25 | 0 | 2 | 1 | 3.55 | .321 | 1.38 | 7.6 | 5.0 | 9.0 | 25.1 | 21 | 10 | 10 | 2 | 14 | 25 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.84 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 59 | 0 | 3 | 0 | 2.82 | .234 | 0.90 | 4.9 | 3.3 | 8.0 | 44.2 | 24 | 16 | 14 | 4 | 16 | 39 | 0 | 6 | 0 | 0 | 0 | 1 | 0 | 3.57 |
| RP | Mota, G.Mota, Guillermo >> | 30 | 2003 | R | 51 | 26 | 0 | 1 | 0 | 3.55 | .317 | 1.39 | 10.1 | 2.5 | 5.5 | 33.0 | 37 | 13 | 13 | 4 | 9 | 20 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.18 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 71 | 19 | 7 | 4 | 4 | 6.26 | .371 | 1.76 | 10.9 | 5.0 | 7.5 | 92.0 | 111 | 64 | 64 | 11 | 51 | 77 | 0 | 0 | 0 | 0 | 2 | 1 | 4 | 4.58 |