| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 25 | 25 | 12 | 10 | 4.06 | .282 | 1.17 | 7.6 | 3.0 | 9.1 | 190.2 | 160 | 88 | 86 | 23 | 63 | 193 | 7 | 0 | 0 | 3 | 12 | 2 | 3 | 3.57 |
| SP | Carpenter, C.Carpenter, Chris † # >> | 34 | 2009 | R | 80 | 24 | 24 | 10 | 7 | 3.57 | .269 | 1.05 | 7.9 | 1.6 | 5.7 | 189.1 | 166 | 77 | 75 | 25 | 33 | 120 | 10 | 0 | 0 | 1 | 15 | 10 | 1 | 4.13 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 76 | 23 | 23 | 9 | 10 | 5.91 | .340 | 1.49 | 10.6 | 2.9 | 9.6 | 141.2 | 166 | 94 | 93 | 19 | 45 | 150 | 0 | 0 | 0 | 0 | 8 | 8 | 2 | 3.75 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 65 | 23 | 23 | 9 | 9 | 5.76 | .339 | 1.50 | 10.8 | 2.8 | 5.9 | 140.2 | 168 | 94 | 90 | 24 | 43 | 91 | 0 | 0 | 0 | 0 | 12 | 5 | 0 | 4.96 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 34 | 23 | 23 | 7 | 4 | 6.26 | .345 | 1.55 | 9.6 | 4.4 | 7.2 | 109.1 | 116 | 76 | 76 | 20 | 53 | 87 | 0 | 0 | 0 | 0 | 4 | 4 | 1 | 5.36 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 76 | 79 | 0 | 5 | 2 | 4.33 | .311 | 1.31 | 8.7 | 3.2 | 9.8 | 54.0 | 52 | 26 | 26 | 6 | 19 | 59 | 0 | 3 | 2 | 0 | 0 | 2 | 4 | 3.43 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 54 | 0 | 1 | 4 | 3.72 | .301 | 1.24 | 8.8 | 2.5 | 8.7 | 55.2 | 54 | 25 | 23 | 8 | 15 | 53 | 0 | 7 | 2 | 0 | 0 | 3 | 2 | 3.95 |