| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 94 | 23 | 22 | 9 | 4 | 3.46 | .285 | 1.18 | 7.6 | 3.0 | 9.1 | 132.2 | 112 | 53 | 51 | 5 | 44 | 134 | 0 | 0 | 0 | 0 | 13 | 3 | 0 | 2.53 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 82 | 23 | 23 | 3 | 14 | 5.27 | .335 | 1.50 | 8.7 | 4.8 | 8.8 | 143.1 | 138 | 90 | 84 | 23 | 77 | 140 | 2 | 0 | 0 | 0 | 7 | 2 | 1 | 4.79 |
| SP | Roark, T.Roark, Tanner >> | 26 | 2013 | R | 74 | 22 | 22 | 0 | 5 | 3.99 | .296 | 1.26 | 9.3 | 2.2 | 4.5 | 58.2 | 60 | 26 | 26 | 5 | 14 | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.84 |
| SP | Nabholz, C.Nabholz, Chris >> | 23 | 1990 | L | 56 | 22 | 21 | 0 | 3 | 4.99 | .338 | 1.49 | 7.8 | 5.7 | 6.6 | 52.1 | 45 | 33 | 29 | 7 | 33 | 38 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5.31 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 73 | 0 | 7 | 6 | 3.73 | .271 | 1.12 | 8.3 | 1.7 | 9.2 | 94.0 | 87 | 42 | 39 | 12 | 18 | 96 | 0 | 1 | 4 | 0 | 0 | 0 | 4 | 3.19 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 75 | 0 | 15 | 6 | 3.69 | .292 | 1.22 | 7.1 | 3.9 | 7.6 | 107.1 | 85 | 48 | 44 | 16 | 46 | 90 | 0 | 0 | 1 | 0 | 0 | 2 | 3 | 4.61 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 76 | 77 | 0 | 7 | 2 | 4.89 | .313 | 1.36 | 9.4 | 2.9 | 8.2 | 99.1 | 103 | 55 | 54 | 19 | 32 | 90 | 0 | 6 | 4 | 0 | 0 | 1 | 0 | 4.68 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 55 | 68 | 0 | 5 | 3 | 3.12 | .293 | 1.23 | 7.2 | 3.9 | 8.9 | 89.1 | 71 | 32 | 31 | 5 | 39 | 88 | 0 | 4 | 1 | 0 | 0 | 1 | 3 | 3.10 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 42 | 61 | 0 | 4 | 8 | 4.92 | .303 | 1.29 | 8.7 | 2.9 | 10.6 | 71.1 | 69 | 40 | 39 | 15 | 23 | 84 | 0 | 5 | 2 | 0 | 0 | 1 | 3 | 4.39 |
| RP | Wetteland, J.Wetteland, John >> | 27 | 1993 | R | 32 | 56 | 0 | 1 | 2 | 3.49 | .345 | 1.57 | 7.8 | 6.3 | 8.6 | 67.0 | 58 | 28 | 26 | 6 | 47 | 64 | 0 | 10 | 3 | 0 | 0 | 1 | 6 | 4.40 |