| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 90 | 28 | 28 | 13 | 7 | 3.96 | .293 | 1.23 | 8.2 | 2.8 | 9.4 | 191.0 | 174 | 88 | 84 | 26 | 60 | 200 | 1 | 0 | 0 | 1 | 17 | 4 | 5 | 3.68 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 87 | 27 | 27 | 14 | 8 | 3.40 | .263 | 1.05 | 7.3 | 2.2 | 6.2 | 220.0 | 179 | 85 | 83 | 29 | 53 | 151 | 13 | 0 | 0 | 5 | 17 | 3 | 1 | 4.10 |
| SP | Scherzer, M.Scherzer, Max >> | 29 | 2013 | R | 76 | 26 | 26 | 10 | 9 | 5.12 | .336 | 1.49 | 9.3 | 4.1 | 8.0 | 167.0 | 172 | 96 | 95 | 23 | 77 | 148 | 1 | 0 | 0 | 0 | 14 | 4 | 3 | 4.47 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 71 | 26 | 26 | 11 | 6 | 4.22 | .318 | 1.39 | 9.0 | 3.5 | 9.6 | 158.0 | 158 | 79 | 74 | 22 | 61 | 168 | 0 | 0 | 0 | 0 | 15 | 2 | 5 | 3.88 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 82 | 66 | 0 | 3 | 4 | 3.00 | .302 | 1.27 | 7.2 | 4.3 | 9.4 | 84.0 | 67 | 31 | 28 | 17 | 40 | 88 | 0 | 10 | 4 | 0 | 0 | 2 | 0 | 5.04 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 71 | 59 | 0 | 5 | 3 | 4.26 | .316 | 1.39 | 7.7 | 4.9 | 10.5 | 61.1 | 52 | 30 | 29 | 10 | 33 | 71 | 0 | 7 | 3 | 0 | 0 | 0 | 3 | 4.43 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 63 | 46 | 0 | 6 | 7 | 4.23 | .310 | 1.30 | 7.6 | 4.1 | 6.1 | 66.0 | 56 | 35 | 31 | 10 | 30 | 45 | 0 | 7 | 4 | 0 | 0 | 3 | 7 | 5.11 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 59 | 23 | 0 | 1 | 1 | 2.67 | .289 | 1.19 | 6.3 | 4.3 | 9.3 | 27.0 | 19 | 10 | 8 | 3 | 13 | 28 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.93 |
| RP | Miller, S.Miller, Shelby >> | 33 | 2024 | R | 42 | 24 | 0 | 2 | 1 | 7.06 | .350 | 1.62 | 10.3 | 4.7 | 6.0 | 21.2 | 24 | 17 | 17 | 5 | 11 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6.33 |
| SP | Podres, J.Podres, Johnny >> | 35 | 1967 | L | 33 | 3 | 0 | 1 | 0 | 5.14 | .323 | 1.43 | 11.6 | 1.3 | 6.4 | 7.0 | 9 | 4 | 4 | 1 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.86 |
| SP | Suggs, G.Suggs, George >> | 27 | 1909 | R | 41 | 19 | 0 | 1 | 1 | 5.02 | .355 | 1.65 | 11.3 | 3.6 | 5.4 | 43.0 | 54 | 27 | 24 | 5 | 17 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.49 |