| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 98 | 28 | 28 | 15 | 7 | 3.40 | .284 | 1.18 | 8.1 | 2.5 | 9.1 | 209.1 | 187 | 83 | 79 | 19 | 59 | 212 | 3 | 0 | 0 | 2 | 16 | 3 | 1 | 3.04 |
| SP | Reulbach, E.Reulbach, Ed # >> | 24 | 1906 | R | 67 | 27 | 27 | 11 | 10 | 3.91 | .319 | 1.38 | 7.8 | 4.6 | 5.2 | 184.0 | 159 | 86 | 80 | 13 | 95 | 106 | 3 | 0 | 0 | 0 | 16 | 4 | 3 | 4.38 |
| SP | Brown, M.Brown, Mordecai # >> | 28 | 1904 | R | 59 | 27 | 27 | 11 | 11 | 5.29 | .334 | 1.48 | 10.2 | 3.0 | 4.5 | 204.0 | 232 | 123 | 120 | 36 | 69 | 103 | 10 | 0 | 0 | 1 | 10 | 6 | 7 | 5.39 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 57 | 26 | 26 | 9 | 13 | 6.00 | .338 | 1.50 | 10.4 | 3.2 | 6.7 | 159.0 | 183 | 106 | 106 | 30 | 56 | 118 | 1 | 0 | 0 | 0 | 9 | 5 | 6 | 5.12 |
| SP | Eckersley, D.Eckersley, Dennis >> | 31 | 1985 | R | 52 | 26 | 25 | 6 | 13 | 6.19 | .342 | 1.53 | 11.2 | 2.6 | 5.3 | 160.0 | 199 | 116 | 110 | 39 | 46 | 94 | 1 | 0 | 0 | 1 | 8 | 5 | 0 | 5.95 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 100 | 72 | 0 | 4 | 2 | 2.76 | .269 | 1.09 | 5.3 | 4.6 | 9.6 | 81.2 | 48 | 27 | 25 | 5 | 41 | 86 | 0 | 3 | 2 | 0 | 0 | 1 | 6 | 3.23 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 91 | 55 | 0 | 2 | 1 | 3.12 | .304 | 1.31 | 7.6 | 4.2 | 8.1 | 52.0 | 44 | 21 | 18 | 4 | 24 | 47 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.58 |
| RP | Hodge, P.Hodge, Porter >> | 23 | 2024 | R | 84 | 39 | 0 | 3 | 1 | 2.60 | .338 | 1.50 | 6.4 | 7.4 | 9.5 | 34.2 | 24 | 12 | 10 | 3 | 28 | 36 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.59 |
| RP | Chafin, A.Chafin, Andrew >> | 31 | 2021 | L | 83 | 57 | 0 | 3 | 3 | 3.19 | .270 | 1.09 | 5.4 | 4.5 | 7.1 | 42.1 | 25 | 15 | 15 | 4 | 21 | 33 | 0 | 8 | 0 | 0 | 0 | 1 | 1 | 4.24 |
| RP | Thielbar, C.Thielbar, Caleb >> | 38 | 2025 | L | 68 | 42 | 0 | 1 | 4 | 4.46 | .331 | 1.46 | 10.8 | 2.5 | 6.8 | 40.1 | 48 | 22 | 20 | 4 | 11 | 30 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 3.70 |