| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 7 | 7 | 2 | 4 | 4.89 | .321 | 1.37 | 8.4 | 4.1 | 10.5 | 42.1 | 39 | 25 | 23 | 6 | 19 | 49 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 4.02 |
| SP | Greinke, Z.Greinke, Zack $ >> | 32 | 2015 | R | 94 | 6 | 6 | 4 | 1 | 4.20 | .311 | 1.33 | 9.6 | 2.4 | 5.0 | 45.0 | 48 | 21 | 21 | 3 | 12 | 25 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 3.62 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 6 | 6 | 0 | 5 | 6.05 | .345 | 1.58 | 10.9 | 3.6 | 7.6 | 38.2 | 46 | 27 | 26 | 5 | 15 | 32 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 4.21 |
| SP | Hernandez, F.Hernandez, Felix # >> | 28 | 2014 | R | 80 | 6 | 6 | 1 | 5 | 4.83 | .317 | 1.37 | 9.0 | 3.3 | 10.1 | 41.0 | 41 | 28 | 22 | 6 | 15 | 46 | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 3.83 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 6 | 6 | 3 | 1 | 4.97 | .337 | 1.47 | 7.3 | 5.9 | 4.0 | 38.0 | 31 | 21 | 21 | 5 | 25 | 17 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 5.95 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 77 | 14 | 0 | 0 | 1 | 4.08 | .243 | 0.91 | 5.8 | 2.6 | 6.4 | 17.2 | 11 | 9 | 8 | 3 | 5 | 12 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 4.94 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 70 | 5 | 0 | 0 | 1 | 2.45 | .154 | 0.55 | 6.0 | 0.0 | 9.0 | 3.2 | 2 | 1 | 1 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.33 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 80 | 3 | 0 | 0 | 0 | 4.15 | .278 | 1.15 | 9.0 | 2.3 | 11.3 | 4.1 | 4 | 2 | 2 | 0 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.25 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 42 | 2 | 0 | 0 | 0 | 5.63 | .333 | 1.38 | 7.9 | 4.5 | 2.3 | 8.0 | 7 | 5 | 5 | 1 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.00 |