| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 28 | 28 | 13 | 8 | 3.69 | .302 | 1.26 | 8.0 | 3.3 | 7.0 | 195.0 | 174 | 80 | 80 | 20 | 72 | 151 | 6 | 0 | 0 | 1 | 17 | 7 | 5 | 4.00 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 28 | 28 | 14 | 10 | 2.74 | .252 | 0.99 | 7.4 | 1.5 | 5.3 | 223.0 | 184 | 77 | 68 | 20 | 37 | 131 | 12 | 0 | 0 | 5 | 19 | 4 | 3 | 3.54 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 81 | 27 | 27 | 14 | 7 | 3.87 | .290 | 1.21 | 7.6 | 3.3 | 8.7 | 165.0 | 139 | 72 | 71 | 20 | 60 | 159 | 0 | 0 | 0 | 0 | 15 | 3 | 4 | 3.79 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 26 | 26 | 15 | 5 | 3.35 | .275 | 1.13 | 8.4 | 1.7 | 5.3 | 191.0 | 179 | 74 | 71 | 24 | 36 | 113 | 5 | 0 | 0 | 2 | 17 | 2 | 1 | 4.05 |
| SP | Gooden, D.Gooden, Dwight † >> | 21 | 1985 | R | 68 | 27 | 27 | 16 | 8 | 3.71 | .294 | 1.23 | 8.3 | 2.8 | 6.0 | 206.1 | 189 | 91 | 85 | 18 | 65 | 137 | 10 | 0 | 0 | 2 | 16 | 4 | 3 | 3.81 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 73 | 0 | 4 | 4 | 2.69 | .256 | 1.02 | 6.4 | 2.8 | 8.1 | 73.2 | 52 | 22 | 22 | 9 | 23 | 66 | 0 | 10 | 2 | 0 | 0 | 1 | 0 | 3.78 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 37 | 0 | 2 | 4 | 3.24 | .269 | 1.06 | 5.0 | 4.6 | 11.2 | 41.2 | 23 | 16 | 15 | 3 | 21 | 51 | 0 | 5 | 0 | 0 | 0 | 2 | 1 | 3.15 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 57 | 27 | 0 | 1 | 0 | 3.91 | .337 | 1.48 | 8.2 | 5.1 | 7.8 | 23.0 | 21 | 11 | 10 | 1 | 13 | 20 | 0 | 8 | 2 | 0 | 0 | 1 | 2 | 3.65 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 15 | 0 | 2 | 0 | 2.63 | .328 | 1.46 | 7.6 | 6.2 | 7.6 | 13.2 | 11 | 4 | 4 | 0 | 9 | 11 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.38 |
| RP | Hiller, J.Hiller, John >> | 30 | 1973 | L | 26 | 76 | 0 | 2 | 0 | 3.86 | .314 | 1.38 | 7.4 | 5.1 | 3.7 | 44.1 | 36 | 19 | 19 | 3 | 25 | 18 | 0 | 5 | 1 | 0 | 0 | 0 | 3 | 4.77 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 16 | 1 | 4 | 4 | 4.58 | .302 | 1.28 | 8.7 | 2.8 | 3.6 | 57.0 | 55 | 35 | 29 | 6 | 18 | 23 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.56 |