| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 29 | 29 | 14 | 6 | 2.47 | .230 | 0.89 | 5.8 | 2.3 | 9.5 | 203.2 | 130 | 62 | 56 | 19 | 51 | 214 | 0 | 0 | 0 | 0 | 24 | 2 | 0 | 2.89 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 27 | 27 | 11 | 12 | 3.42 | .295 | 1.24 | 7.9 | 3.2 | 7.8 | 205.0 | 180 | 87 | 78 | 21 | 74 | 177 | 6 | 0 | 0 | 1 | 19 | 3 | 2 | 3.73 |
| SP | McLain, D.McLain, Denny † # >> | 24 | 1968 | R | 79 | 27 | 27 | 13 | 10 | 4.28 | .277 | 1.14 | 8.3 | 2.0 | 5.8 | 197.2 | 181 | 96 | 94 | 34 | 44 | 126 | 12 | 0 | 0 | 2 | 12 | 2 | 8 | 4.66 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 27 | 26 | 12 | 11 | 5.51 | .312 | 1.34 | 8.7 | 3.4 | 5.9 | 170.0 | 164 | 104 | 104 | 23 | 64 | 112 | 8 | 0 | 0 | 2 | 12 | 3 | 4 | 4.62 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 64 | 0 | 6 | 3 | 3.38 | .266 | 1.09 | 6.9 | 2.9 | 9.7 | 77.1 | 59 | 38 | 29 | 9 | 25 | 83 | 0 | 9 | 1 | 0 | 0 | 0 | 1 | 3.34 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 44 | 0 | 4 | 2 | 2.86 | .313 | 1.32 | 7.0 | 4.9 | 7.2 | 44.0 | 34 | 16 | 14 | 5 | 24 | 35 | 0 | 9 | 2 | 0 | 0 | 2 | 0 | 4.66 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 16 | 0 | 2 | 0 | 1.02 | .274 | 1.08 | 7.4 | 2.6 | 10.6 | 17.2 | 14 | 2 | 2 | 1 | 5 | 20 | 0 | 5 | 1 | 0 | 0 | 1 | 1 | 2.47 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 9 | 0 | 0 | 2 | 3.09 | .286 | 1.20 | 8.2 | 3.3 | 9.0 | 11.2 | 10 | 5 | 4 | 2 | 4 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.45 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 19 | 0 | 1 | 0 | 4.50 | .355 | 1.55 | 9.0 | 5.0 | 8.1 | 20.0 | 20 | 11 | 10 | 2 | 11 | 18 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.45 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 51 | 12 | 0 | 1 | 2 | 3.86 | .332 | 1.47 | 9.5 | 3.9 | 6.5 | 53.2 | 56 | 25 | 23 | 6 | 23 | 38 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.40 |