| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 15 | 15 | 5 | 2 | 3.79 | .278 | 1.14 | 8.5 | 1.9 | 9.8 | 92.2 | 87 | 47 | 39 | 15 | 19 | 100 | 0 | 0 | 0 | 0 | 11 | 1 | 0 | 3.60 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 15 | 15 | 4 | 8 | 3.97 | .297 | 1.27 | 9.1 | 2.3 | 9.3 | 93.0 | 94 | 46 | 41 | 15 | 24 | 96 | 2 | 0 | 0 | 0 | 9 | 0 | 4 | 3.81 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 81 | 14 | 14 | 3 | 6 | 5.12 | .331 | 1.45 | 9.9 | 3.2 | 4.7 | 84.1 | 92 | 55 | 48 | 15 | 30 | 44 | 3 | 0 | 0 | 0 | 5 | 3 | 2 | 5.45 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 15 | 13 | 1 | 6 | 6.69 | .355 | 1.64 | 10.7 | 4.0 | 5.8 | 74.0 | 88 | 57 | 55 | 15 | 33 | 48 | 1 | 0 | 0 | 0 | 3 | 1 | 3 | 5.72 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 38 | 0 | 3 | 7 | 5.36 | .324 | 1.44 | 9.5 | 3.6 | 8.6 | 40.1 | 42 | 27 | 24 | 5 | 16 | 38 | 0 | 5 | 5 | 0 | 0 | 0 | 2 | 3.93 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 43 | 0 | 3 | 2 | 6.66 | .339 | 1.54 | 12.4 | 1.4 | 7.7 | 50.0 | 69 | 37 | 37 | 7 | 8 | 43 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.58 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 40 | 0 | 0 | 1 | 5.72 | .366 | 1.70 | 9.9 | 5.5 | 10.6 | 39.1 | 43 | 25 | 25 | 3 | 24 | 46 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 3.56 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 34 | 0 | 4 | 1 | 3.11 | .280 | 1.17 | 7.8 | 2.7 | 9.0 | 46.1 | 40 | 20 | 16 | 4 | 14 | 46 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.04 |