| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 95 | 23 | 23 | 4 | 12 | 3.94 | .292 | 1.20 | 8.3 | 2.5 | 8.7 | 164.1 | 152 | 84 | 72 | 18 | 46 | 158 | 3 | 0 | 0 | 0 | 12 | 5 | 5 | 3.43 |
| SP | Nelson, R.Nelson, Roger # >> | 28 | 1972 | R | 87 | 22 | 22 | 8 | 6 | 5.42 | .327 | 1.43 | 10.1 | 2.8 | 5.4 | 111.1 | 124 | 73 | 67 | 16 | 35 | 66 | 0 | 0 | 0 | 0 | 5 | 3 | 4 | 4.71 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 65 | 22 | 22 | 8 | 9 | 4.34 | .320 | 1.40 | 8.7 | 3.8 | 6.7 | 141.0 | 137 | 73 | 68 | 17 | 60 | 105 | 1 | 0 | 0 | 1 | 12 | 2 | 0 | 4.40 |
| SP | DeLeon, J.DeLeon, Jose >> | 29 | 1989 | R | 60 | 22 | 22 | 5 | 12 | 6.89 | .364 | 1.66 | 9.4 | 5.5 | 6.4 | 125.1 | 131 | 109 | 96 | 25 | 77 | 89 | 0 | 0 | 0 | 0 | 7 | 7 | 3 | 6.19 |
| SP | Candelaria, J.Candelaria, John >> | 33 | 1986 | L | 54 | 21 | 21 | 6 | 11 | 4.95 | .335 | 1.48 | 9.1 | 4.3 | 7.8 | 116.1 | 117 | 68 | 64 | 16 | 55 | 101 | 0 | 0 | 0 | 0 | 8 | 4 | 7 | 4.58 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 93 | 62 | 0 | 4 | 3 | 3.75 | .274 | 1.10 | 7.2 | 2.7 | 9.6 | 84.0 | 67 | 38 | 35 | 7 | 25 | 90 | 0 | 5 | 3 | 0 | 0 | 3 | 0 | 2.94 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 63 | 56 | 0 | 3 | 4 | 6.51 | .364 | 1.70 | 12.0 | 3.4 | 6.8 | 66.1 | 88 | 51 | 48 | 12 | 25 | 50 | 0 | 4 | 4 | 0 | 0 | 1 | 1 | 5.03 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 55 | 47 | 0 | 4 | 2 | 2.79 | .300 | 1.29 | 7.5 | 4.1 | 11.2 | 61.1 | 51 | 19 | 19 | 3 | 28 | 76 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 2.52 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 48 | 39 | 0 | 3 | 3 | 2.62 | .298 | 1.23 | 6.5 | 4.7 | 8.8 | 44.2 | 32 | 13 | 13 | 4 | 23 | 43 | 0 | 5 | 0 | 0 | 0 | 2 | 1 | 3.93 |
| RP | Mantei, M.Mantei, Matt >> | 30 | 2003 | R | 39 | 26 | 0 | 0 | 1 | 5.28 | .338 | 1.53 | 11.7 | 2.4 | 9.0 | 30.2 | 39 | 18 | 18 | 5 | 8 | 30 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3.97 |