| SP | Arrieta, J.Arrieta, Jake $$ >> | 29 | 2015 | R | 95 | 34 | 34 | 11 | 14 | 4.93 | .312 | 1.33 | 9.1 | 2.9 | 7.6 | 190.0 | 192 | 108 | 104 | 28 | 61 | 161 | 3 | 0 | 0 | 0 | 17 | 6 | 8 | 4.28 |
| SP | Liriano, F.Liriano, Francisco # >> | 23 | 2006 | L | 74 | 33 | 33 | 9 | 12 | 4.64 | .319 | 1.35 | 9.8 | 2.4 | 10.2 | 165.0 | 179 | 85 | 85 | 23 | 44 | 187 | 0 | 0 | 0 | 0 | 8 | 9 | 3 | 3.51 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 67 | 33 | 33 | 13 | 13 | 3.99 | .295 | 1.24 | 8.3 | 3.0 | 6.3 | 209.2 | 192 | 104 | 93 | 29 | 69 | 146 | 6 | 0 | 0 | 0 | 16 | 2 | 4 | 4.43 |
| CL | Jansen, K.Jansen, Kenley † $$ >> | 28 | 2016 | R | 96 | 75 | 0 | 3 | 0 | 1.82 | .275 | 1.13 | 7.3 | 2.8 | 9.7 | 79.0 | 64 | 17 | 16 | 3 | 25 | 85 | 0 | 37 | 4 | 0 | 0 | 1 | 0 | 2.33 |
| SU | Benoit, J.Benoit, Joaquin # >> | 33 | 2010 | R | 94 | 81 | 0 | 1 | 3 | 3.63 | .290 | 1.22 | 7.7 | 3.3 | 8.8 | 86.2 | 74 | 38 | 35 | 12 | 32 | 84 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 3.98 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 77 | 84 | 0 | 9 | 1 | 3.09 | .300 | 1.27 | 7.9 | 3.6 | 8.3 | 113.2 | 99 | 44 | 39 | 11 | 45 | 104 | 0 | 2 | 1 | 0 | 0 | 2 | 2 | 3.67 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 70 | 75 | 0 | 3 | 4 | 3.59 | .304 | 1.28 | 7.1 | 4.4 | 9.5 | 85.1 | 67 | 34 | 34 | 16 | 42 | 90 | 0 | 3 | 2 | 0 | 0 | 3 | 4 | 4.92 |
| RP | Gregerson, L.Gregerson, Luke # >> | 26 | 2010 | R | 70 | 59 | 0 | 4 | 3 | 5.49 | .326 | 1.42 | 9.5 | 3.5 | 9.3 | 78.2 | 82 | 48 | 48 | 17 | 30 | 81 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 4.99 |