| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 23 | 23 | 4 | 11 | 4.95 | .335 | 1.49 | 8.9 | 4.5 | 9.9 | 145.1 | 144 | 84 | 80 | 30 | 72 | 159 | 1 | 0 | 0 | 0 | 10 | 4 | 3 | 5.07 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 83 | 22 | 22 | 7 | 9 | 3.98 | .311 | 1.33 | 7.8 | 4.2 | 9.5 | 138.0 | 120 | 64 | 61 | 17 | 64 | 146 | 0 | 0 | 0 | 0 | 14 | 3 | 2 | 3.94 |
| SP | Hudson, D.Hudson, Daniel # >> | 23 | 2010 | R | 73 | 22 | 22 | 9 | 9 | 3.88 | .289 | 1.18 | 7.5 | 3.2 | 7.5 | 162.1 | 135 | 73 | 70 | 21 | 57 | 135 | 4 | 0 | 0 | 1 | 12 | 6 | 6 | 4.19 |
| SP | Higuera, T.Higuera, Teddy >> | 30 | 1988 | L | 64 | 22 | 22 | 7 | 11 | 5.60 | .335 | 1.47 | 9.7 | 3.5 | 7.0 | 151.0 | 163 | 103 | 94 | 35 | 59 | 118 | 3 | 0 | 0 | 0 | 11 | 6 | 0 | 5.74 |
| SP | Beckett, J.Beckett, Josh >> | 31 | 2011 | R | 58 | 21 | 21 | 4 | 12 | 5.99 | .348 | 1.56 | 9.9 | 4.2 | 6.3 | 135.1 | 148 | 91 | 90 | 17 | 63 | 95 | 1 | 0 | 0 | 0 | 8 | 6 | 3 | 4.76 |
| RP | Street, H.Street, Huston # >> | 29 | 2012 | R | 95 | 59 | 0 | 4 | 3 | 4.81 | .332 | 1.47 | 8.4 | 4.8 | 9.9 | 73.0 | 68 | 41 | 39 | 15 | 39 | 80 | 0 | 4 | 5 | 0 | 0 | 2 | 0 | 5.16 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 52 | 0 | 3 | 2 | 2.76 | .268 | 1.08 | 6.2 | 3.5 | 9.6 | 62.0 | 43 | 20 | 19 | 5 | 24 | 66 | 0 | 4 | 2 | 0 | 0 | 1 | 2 | 3.13 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 60 | 45 | 0 | 2 | 4 | 7.29 | .370 | 1.71 | 11.4 | 4.1 | 8.6 | 42.0 | 53 | 34 | 34 | 11 | 19 | 40 | 0 | 6 | 2 | 0 | 0 | 2 | 3 | 6.00 |
| RP | Pressly, R.Pressly, Ryan >> | 30 | 2019 | R | 53 | 29 | 0 | 0 | 3 | 3.90 | .331 | 1.48 | 8.7 | 4.8 | 11.8 | 32.1 | 31 | 14 | 14 | 4 | 17 | 42 | 0 | 4 | 3 | 0 | 0 | 0 | 0 | 3.59 |