| SP | Richard, J.Richard, J.R. † >> | 30 | 1980 | R | 93 | 23 | 23 | 14 | 5 | 3.74 | .300 | 1.27 | 6.5 | 5.0 | 7.9 | 154.0 | 111 | 64 | 64 | 14 | 85 | 135 | 1 | 0 | 0 | 1 | 18 | 2 | 5 | 4.12 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 90 | 22 | 22 | 11 | 7 | 3.38 | .282 | 1.17 | 8.3 | 2.2 | 5.8 | 173.0 | 160 | 73 | 65 | 12 | 43 | 111 | 8 | 0 | 0 | 1 | 13 | 1 | 1 | 3.38 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 78 | 22 | 22 | 9 | 10 | 4.48 | .293 | 1.22 | 8.5 | 2.5 | 5.1 | 156.2 | 148 | 78 | 78 | 30 | 43 | 89 | 4 | 0 | 0 | 1 | 11 | 4 | 6 | 5.26 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 20 | 20 | 10 | 5 | 3.16 | .283 | 1.15 | 6.3 | 4.0 | 8.3 | 131.0 | 92 | 48 | 46 | 10 | 58 | 121 | 1 | 0 | 0 | 1 | 15 | 5 | 2 | 3.59 |
| SP | Strasburg, S.Strasburg, Stephen >> | 28 | 2017 | R | 65 | 20 | 20 | 9 | 4 | 4.29 | .308 | 1.28 | 8.5 | 3.1 | 8.7 | 136.1 | 128 | 66 | 65 | 18 | 47 | 131 | 1 | 0 | 0 | 0 | 12 | 7 | 4 | 3.99 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 65 | 0 | 3 | 3 | 2.19 | .212 | 0.79 | 4.7 | 2.5 | 9.8 | 65.2 | 34 | 18 | 16 | 10 | 18 | 71 | 0 | 12 | 5 | 0 | 0 | 1 | 0 | 3.69 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 85 | 64 | 0 | 5 | 2 | 2.64 | .313 | 1.37 | 9.6 | 3.0 | 13.2 | 30.2 | 32 | 10 | 9 | 2 | 10 | 44 | 0 | 3 | 1 | 0 | 0 | 0 | 3 | 1.93 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 82 | 32 | 0 | 2 | 0 | 2.38 | .292 | 1.24 | 6.9 | 4.2 | 7.4 | 34.0 | 26 | 11 | 9 | 2 | 16 | 28 | 0 | 9 | 0 | 0 | 0 | 0 | 0 | 3.53 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 26 | 0 | 3 | 3 | 2.49 | .283 | 1.14 | 6.1 | 4.3 | 11.5 | 25.1 | 17 | 9 | 7 | 3 | 12 | 32 | 0 | 6 | 1 | 0 | 0 | 1 | 3 | 3.56 |