| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 23 | 23 | 6 | 4 | 3.18 | .271 | 1.07 | 7.7 | 1.9 | 6.0 | 170.0 | 146 | 63 | 60 | 24 | 36 | 114 | 4 | 0 | 0 | 0 | 14 | 8 | 5 | 4.27 |
| SP | Fernandez, S.Fernandez, Sid † $ >> | 23 | 1985 | L | 52 | 22 | 22 | 15 | 4 | 2.65 | .270 | 1.06 | 5.5 | 4.1 | 8.4 | 153.0 | 93 | 48 | 45 | 14 | 69 | 143 | 2 | 0 | 0 | 0 | 19 | 8 | 3 | 3.83 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 87 | 21 | 21 | 9 | 9 | 3.12 | .268 | 1.07 | 7.4 | 2.3 | 7.9 | 155.2 | 128 | 57 | 54 | 15 | 39 | 136 | 5 | 0 | 0 | 2 | 15 | 4 | 4 | 3.34 |
| SP | Carlton, S.Carlton, Steve † >> | 28 | 1972 | L | 68 | 21 | 21 | 11 | 5 | 3.55 | .286 | 1.17 | 7.7 | 2.9 | 6.3 | 164.2 | 140 | 68 | 65 | 14 | 52 | 114 | 8 | 0 | 0 | 1 | 14 | 6 | 2 | 3.78 |
| RP | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 56 | 0 | 4 | 1 | 1.84 | .225 | 0.83 | 5.3 | 2.2 | 8.8 | 73.1 | 43 | 15 | 15 | 8 | 18 | 71 | 0 | 7 | 3 | 0 | 0 | 3 | 1 | 3.34 |
| RP | Papelbon, J.Papelbon, Jonathan † >> | 27 | 2007 | R | 91 | 43 | 0 | 7 | 3 | 0.95 | .215 | 0.80 | 4.6 | 2.7 | 10.3 | 47.1 | 24 | 5 | 5 | 4 | 14 | 54 | 0 | 10 | 0 | 0 | 0 | 1 | 0 | 2.77 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 86 | 18 | 0 | 4 | 0 | 1.13 | .200 | 0.75 | 5.6 | 1.1 | 9.8 | 24.0 | 15 | 3 | 3 | 0 | 3 | 26 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.21 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 12 | 0 | 0 | 2 | 5.02 | .295 | 1.19 | 9.0 | 1.9 | 10.3 | 14.1 | 14 | 8 | 8 | 2 | 3 | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.43 |
| SP | Flaherty, J.Flaherty, Jack >> | 23 | 2019 | R | 82 | 13 | 1 | 5 | 1 | 2.90 | .259 | 1.03 | 7.2 | 2.2 | 10.5 | 49.2 | 39 | 16 | 16 | 8 | 12 | 57 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 3.59 |