| SP | deGrom, J.deGrom, Jacob † $ >> | 33 | 2021 | R | 100 | 28 | 28 | 17 | 6 | 2.91 | .249 | 0.97 | 6.6 | 2.1 | 10.2 | 195.0 | 143 | 63 | 63 | 30 | 46 | 222 | 2 | 0 | 0 | 1 | 22 | 5 | 0 | 3.51 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 84 | 27 | 27 | 13 | 9 | 3.77 | .293 | 1.23 | 8.4 | 2.8 | 5.7 | 214.2 | 199 | 92 | 90 | 30 | 66 | 136 | 11 | 0 | 0 | 2 | 13 | 2 | 2 | 4.50 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 78 | 26 | 26 | 12 | 6 | 3.78 | .314 | 1.34 | 8.6 | 3.5 | 6.5 | 183.1 | 175 | 80 | 77 | 22 | 71 | 133 | 5 | 0 | 0 | 0 | 18 | 6 | 3 | 4.37 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 26 | 26 | 11 | 5 | 3.78 | .301 | 1.28 | 7.6 | 3.9 | 8.7 | 159.1 | 135 | 67 | 67 | 17 | 69 | 153 | 0 | 0 | 0 | 0 | 16 | 2 | 2 | 3.81 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 73 | 25 | 25 | 12 | 7 | 4.26 | .303 | 1.26 | 8.1 | 3.2 | 6.6 | 190.1 | 171 | 90 | 90 | 26 | 68 | 140 | 8 | 0 | 0 | 1 | 11 | 9 | 6 | 4.52 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 68 | 0 | 8 | 5 | 3.51 | .286 | 1.19 | 7.4 | 3.3 | 9.4 | 100.0 | 82 | 46 | 39 | 12 | 37 | 104 | 0 | 13 | 4 | 0 | 0 | 1 | 0 | 3.62 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 81 | 30 | 0 | 3 | 1 | 2.56 | .275 | 1.14 | 6.2 | 4.3 | 8.5 | 38.2 | 26 | 11 | 11 | 4 | 18 | 36 | 0 | 3 | 0 | 0 | 0 | 0 | 2 | 3.89 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 78 | 21 | 0 | 2 | 0 | 2.22 | .263 | 1.03 | 6.4 | 3.0 | 11.3 | 24.1 | 17 | 6 | 6 | 1 | 8 | 30 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 2.17 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 77 | 20 | 0 | 0 | 4 | 3.18 | .253 | 0.97 | 5.7 | 3.3 | 4.9 | 22.2 | 14 | 9 | 8 | 5 | 8 | 12 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 6.09 |
| RP | Balfour, G.Balfour, Grant $ >> | 31 | 2008 | R | 73 | 21 | 0 | 2 | 1 | 6.75 | .354 | 1.64 | 10.3 | 4.7 | 6.0 | 21.1 | 24 | 16 | 16 | 4 | 11 | 14 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.71 |
| SP | McNally, D.McNally, Dave >> | 29 | 1971 | L | 16 | 2 | 0 | 1 | 0 | 22.50 | .455 | 2.50 | 22.5 | 0.0 | 0.0 | 2.0 | 5 | 5 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 16.00 |