| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 7 | 7 | 1 | 4 | 4.18 | .317 | 1.37 | 8.8 | 3.6 | 10.3 | 47.1 | 46 | 22 | 22 | 7 | 19 | 54 | 1 | 0 | 0 | 0 | 3 | 1 | 0 | 3.91 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 85 | 6 | 6 | 5 | 0 | 3.52 | .299 | 1.26 | 9.0 | 2.3 | 5.5 | 46.0 | 46 | 19 | 18 | 6 | 12 | 28 | 2 | 0 | 0 | 1 | 4 | 1 | 1 | 4.33 |
| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 86 | 6 | 6 | 1 | 4 | 6.88 | .366 | 1.74 | 11.9 | 3.7 | 6.1 | 34.0 | 45 | 26 | 26 | 5 | 14 | 23 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4.79 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 6 | 6 | 3 | 2 | 5.66 | .367 | 1.69 | 12.1 | 3.1 | 4.4 | 35.0 | 47 | 22 | 22 | 6 | 12 | 17 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 5.46 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 69 | 6 | 6 | 5 | 0 | 2.37 | .337 | 1.50 | 8.3 | 5.2 | 6.2 | 38.0 | 35 | 10 | 10 | 1 | 22 | 26 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 3.79 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 94 | 15 | 0 | 1 | 3 | 6.00 | .308 | 1.33 | 9.9 | 2.1 | 7.7 | 21.0 | 23 | 14 | 14 | 2 | 5 | 18 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 3.24 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 10 | 0 | 1 | 0 | 1.42 | .156 | 0.55 | 5.3 | 0.0 | 7.5 | 12.2 | 7 | 2 | 2 | 1 | 0 | 10 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2.42 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 5 | 0 | 0 | 0 | 4.76 | .261 | 1.06 | 9.0 | 1.8 | 16.2 | 5.2 | 5 | 3 | 3 | 1 | 1 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.60 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 76 | 7 | 0 | 0 | 0 | 5.40 | .250 | 1.00 | 7.2 | 1.8 | 9.0 | 5.0 | 4 | 3 | 3 | 3 | 1 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 9.40 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 67 | 5 | 0 | 0 | 1 | 1.46 | .275 | 1.14 | 9.8 | 0.8 | 7.5 | 12.1 | 13 | 7 | 2 | 0 | 1 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.58 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 4 | 0 | 0 | 0 | 5.85 | .326 | 1.35 | 9.0 | 3.2 | 5.9 | 20.0 | 20 | 13 | 13 | 5 | 7 | 13 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 6.30 |