| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 99 | 28 | 28 | 6 | 15 | 5.50 | .344 | 1.53 | 10.6 | 3.3 | 8.1 | 168.2 | 197 | 105 | 103 | 33 | 61 | 152 | 1 | 0 | 0 | 0 | 12 | 7 | 2 | 4.96 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 82 | 28 | 28 | 10 | 9 | 3.99 | .307 | 1.31 | 8.7 | 3.1 | 6.8 | 189.2 | 183 | 92 | 84 | 17 | 66 | 142 | 1 | 0 | 0 | 0 | 16 | 3 | 6 | 3.76 |
| SP | Williams, W.Williams, Woody >> | 36 | 2002 | R | 79 | 27 | 27 | 4 | 11 | 7.16 | .374 | 1.76 | 11.9 | 3.9 | 7.2 | 138.1 | 183 | 114 | 110 | 34 | 60 | 111 | 0 | 0 | 0 | 0 | 7 | 5 | 4 | 6.01 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 27 | 27 | 0 | 5 | 4.95 | .335 | 1.49 | 9.5 | 3.9 | 6.7 | 116.1 | 123 | 67 | 64 | 17 | 50 | 86 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 4.79 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 85 | 67 | 0 | 8 | 0 | 3.16 | .279 | 1.13 | 5.7 | 4.4 | 9.2 | 94.0 | 60 | 34 | 33 | 7 | 46 | 96 | 0 | 0 | 1 | 0 | 0 | 3 | 3 | 3.49 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 63 | 0 | 6 | 3 | 4.56 | .336 | 1.51 | 8.0 | 5.6 | 9.3 | 81.0 | 72 | 43 | 41 | 10 | 50 | 84 | 0 | 0 | 3 | 0 | 0 | 1 | 5 | 4.42 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 56 | 0 | 2 | 5 | 4.27 | .324 | 1.40 | 10.3 | 2.4 | 11.9 | 71.2 | 81 | 35 | 34 | 11 | 19 | 94 | 0 | 1 | 4 | 0 | 0 | 3 | 4 | 3.30 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 49 | 0 | 2 | 3 | 5.17 | .339 | 1.46 | 8.7 | 4.5 | 10.3 | 54.0 | 52 | 32 | 31 | 11 | 27 | 62 | 0 | 0 | 3 | 0 | 0 | 4 | 1 | 5.07 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 48 | 0 | 3 | 5 | 5.30 | .358 | 1.67 | 11.9 | 3.3 | 7.1 | 52.2 | 69 | 37 | 31 | 9 | 19 | 41 | 0 | 2 | 2 | 0 | 0 | 0 | 2 | 4.77 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 69 | 7 | 0 | 2 | 0 | 5.17 | .338 | 1.47 | 12.0 | 1.8 | 7.8 | 15.2 | 20 | 10 | 9 | 3 | 3 | 13 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.67 |