| SP | Koufax, S.Koufax, Sandy $ >> | 30 | 1965 | L | 97 | 33 | 33 | 13 | 14 | 4.81 | .320 | 1.38 | 8.7 | 3.7 | 7.9 | 221.0 | 214 | 130 | 118 | 31 | 92 | 195 | 4 | 0 | 0 | 0 | 14 | 6 | 7 | 4.39 |
| SP | Scott, M.Scott, Mike $ >> | 31 | 1986 | R | 87 | 32 | 32 | 12 | 15 | 5.38 | .341 | 1.53 | 9.5 | 4.3 | 7.3 | 197.1 | 208 | 128 | 118 | 35 | 94 | 160 | 3 | 0 | 0 | 1 | 14 | 5 | 3 | 5.19 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 30 | 30 | 8 | 14 | 5.83 | .342 | 1.53 | 10.6 | 3.3 | 8.4 | 163.2 | 192 | 108 | 106 | 30 | 59 | 152 | 0 | 0 | 0 | 0 | 12 | 4 | 5 | 4.69 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 84 | 31 | 31 | 10 | 12 | 5.17 | .313 | 1.36 | 9.8 | 2.4 | 5.2 | 202.0 | 220 | 119 | 116 | 20 | 54 | 117 | 4 | 0 | 0 | 1 | 14 | 2 | 4 | 3.96 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 30 | 30 | 10 | 14 | 5.85 | .315 | 1.35 | 9.5 | 2.6 | 5.7 | 194.0 | 204 | 131 | 126 | 42 | 57 | 123 | 8 | 0 | 0 | 1 | 9 | 7 | 7 | 5.54 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 57 | 0 | 5 | 12 | 5.40 | .309 | 1.32 | 9.5 | 2.6 | 8.7 | 56.2 | 59 | 37 | 34 | 15 | 16 | 54 | 0 | 27 | 8 | 0 | 0 | 1 | 2 | 5.46 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 72 | 0 | 1 | 4 | 5.18 | .311 | 1.32 | 8.3 | 3.7 | 9.0 | 88.2 | 81 | 51 | 51 | 10 | 36 | 88 | 0 | 4 | 2 | 0 | 0 | 3 | 0 | 3.81 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 49 | 0 | 3 | 0 | 4.12 | .311 | 1.35 | 8.8 | 3.5 | 7.7 | 54.2 | 53 | 25 | 25 | 8 | 21 | 46 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.39 |
| SU | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 48 | 0 | 0 | 0 | 3.14 | .295 | 1.26 | 7.6 | 3.9 | 9.5 | 51.2 | 43 | 19 | 18 | 3 | 22 | 54 | 0 | 3 | 7 | 0 | 0 | 0 | 1 | 2.94 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 38 | 0 | 1 | 1 | 2.47 | .225 | 0.87 | 6.3 | 1.7 | 9.4 | 43.2 | 30 | 12 | 12 | 3 | 8 | 45 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.37 |