| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 33 | 33 | 20 | 7 | 3.17 | .255 | 1.01 | 7.1 | 2.1 | 8.4 | 255.1 | 200 | 94 | 90 | 30 | 59 | 237 | 12 | 0 | 0 | 2 | 23 | 3 | 6 | 3.40 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 31 | 31 | 17 | 9 | 3.66 | .290 | 1.20 | 7.6 | 3.2 | 4.9 | 233.1 | 197 | 99 | 95 | 28 | 83 | 128 | 9 | 0 | 0 | 2 | 17 | 6 | 0 | 4.61 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 78 | 28 | 28 | 13 | 10 | 4.79 | .320 | 1.37 | 9.4 | 2.9 | 5.6 | 193.1 | 202 | 108 | 103 | 31 | 63 | 120 | 6 | 0 | 0 | 1 | 13 | 8 | 3 | 4.95 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 81 | 30 | 30 | 13 | 10 | 3.95 | .288 | 1.19 | 7.8 | 2.9 | 4.8 | 214.1 | 186 | 96 | 94 | 25 | 69 | 115 | 7 | 0 | 0 | 2 | 13 | 5 | 2 | 4.48 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 66 | 0 | 5 | 2 | 2.97 | .286 | 1.16 | 7.0 | 3.5 | 9.1 | 66.2 | 51 | 22 | 22 | 6 | 26 | 67 | 0 | 7 | 2 | 0 | 0 | 3 | 0 | 3.47 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 12 | 0 | 1 | 0 | 0.96 | .200 | 0.75 | 5.5 | 1.5 | 4.0 | 18.2 | 11 | 2 | 2 | 0 | 3 | 8 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 2.61 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 11 | 0 | 1 | 1 | 6.17 | .314 | 1.29 | 9.0 | 3.3 | 14.7 | 11.2 | 11 | 8 | 8 | 1 | 4 | 18 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 2.27 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 20 | 0 | 3 | 0 | 6.16 | .380 | 1.84 | 10.9 | 5.7 | 7.1 | 19.0 | 23 | 14 | 13 | 3 | 12 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 5.37 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 13 | 0 | 1 | 0 | 3.86 | .338 | 1.47 | 6.8 | 6.8 | 6.2 | 16.1 | 12 | 7 | 7 | 2 | 12 | 11 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.69 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 11 | 4 | 3 | 2 | 4.50 | .291 | 1.23 | 8.3 | 2.9 | 7.1 | 60.0 | 55 | 32 | 30 | 11 | 19 | 47 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 4.77 |