| SP | deGrom, J.deGrom, Jacob † $ >> | 33 | 2021 | R | 100 | 21 | 21 | 14 | 4 | 2.94 | .279 | 1.13 | 6.8 | 3.4 | 8.8 | 134.2 | 101 | 45 | 44 | 13 | 51 | 131 | 0 | 0 | 0 | 0 | 16 | 4 | 0 | 3.54 |
| SP | Greinke, Z.Greinke, Zack † >> | 32 | 2015 | R | 94 | 21 | 21 | 12 | 4 | 3.34 | .280 | 1.15 | 7.5 | 2.8 | 5.1 | 140.0 | 117 | 55 | 52 | 11 | 44 | 80 | 4 | 0 | 0 | 2 | 14 | 2 | 4 | 3.86 |
| SP | Hearn, J.Hearn, Jim $$ >> | 29 | 1950 | R | 76 | 20 | 20 | 9 | 3 | 3.08 | .284 | 1.16 | 6.4 | 4.1 | 3.4 | 131.1 | 93 | 47 | 45 | 8 | 60 | 50 | 2 | 0 | 0 | 2 | 15 | 3 | 1 | 4.47 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 19 | 19 | 7 | 7 | 3.75 | .301 | 1.27 | 8.4 | 3.0 | 8.9 | 124.2 | 116 | 56 | 52 | 20 | 42 | 122 | 2 | 0 | 0 | 1 | 10 | 3 | 3 | 4.22 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 55 | 0 | 5 | 0 | 3.04 | .243 | 0.94 | 6.4 | 2.0 | 8.2 | 77.0 | 55 | 27 | 26 | 9 | 17 | 70 | 0 | 3 | 1 | 0 | 0 | 2 | 5 | 3.44 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 29 | 0 | 1 | 2 | 3.06 | .259 | 1.02 | 8.7 | 0.5 | 9.0 | 35.1 | 34 | 14 | 12 | 6 | 2 | 35 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 3.49 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 21 | 0 | 2 | 0 | 2.45 | .260 | 1.01 | 5.0 | 4.3 | 8.3 | 25.2 | 14 | 8 | 7 | 3 | 12 | 23 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 4.28 |