| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 21 | 21 | 5 | 11 | 5.65 | .314 | 1.37 | 10.2 | 2.2 | 8.7 | 116.1 | 131 | 81 | 73 | 22 | 28 | 112 | 1 | 0 | 0 | 0 | 9 | 1 | 3 | 4.28 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 20 | 20 | 8 | 7 | 3.65 | .289 | 1.20 | 6.5 | 4.4 | 5.3 | 120.2 | 86 | 59 | 49 | 10 | 59 | 71 | 1 | 0 | 0 | 0 | 12 | 2 | 0 | 4.43 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 49 | 0 | 2 | 5 | 2.44 | .225 | 0.87 | 6.0 | 1.9 | 9.7 | 51.2 | 34 | 17 | 14 | 6 | 11 | 55 | 0 | 19 | 3 | 0 | 0 | 0 | 0 | 3.02 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 50 | 0 | 4 | 2 | 3.21 | .286 | 1.18 | 6.9 | 3.8 | 10.2 | 61.2 | 47 | 27 | 22 | 7 | 26 | 69 | 0 | 1 | 5 | 0 | 0 | 1 | 0 | 3.56 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 49 | 0 | 1 | 3 | 3.19 | .264 | 1.08 | 7.6 | 2.1 | 7.9 | 59.1 | 50 | 28 | 21 | 7 | 14 | 52 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 3.49 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 31 | 0 | 3 | 0 | 3.55 | .325 | 1.42 | 9.0 | 3.8 | 10.2 | 38.0 | 38 | 15 | 15 | 5 | 16 | 43 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 3.79 |