| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 34 | 34 | 14 | 15 | 4.28 | .311 | 1.34 | 8.9 | 3.2 | 8.0 | 258.2 | 255 | 123 | 123 | 34 | 92 | 230 | 10 | 0 | 0 | 0 | 16 | 3 | 7 | 4.03 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 33 | 33 | 9 | 12 | 5.12 | .324 | 1.41 | 9.6 | 3.1 | 4.9 | 170.2 | 182 | 101 | 97 | 25 | 58 | 92 | 0 | 0 | 0 | 0 | 8 | 5 | 4 | 4.94 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 69 | 32 | 32 | 10 | 16 | 5.30 | .351 | 1.62 | 11.1 | 3.6 | 5.5 | 212.1 | 261 | 141 | 125 | 31 | 84 | 130 | 2 | 0 | 0 | 1 | 13 | 0 | 9 | 4.86 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 32 | 32 | 7 | 19 | 6.53 | .355 | 1.62 | 11.5 | 3.2 | 4.0 | 205.1 | 261 | 154 | 149 | 27 | 72 | 92 | 1 | 0 | 0 | 0 | 9 | 6 | 8 | 4.96 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 31 | 31 | 15 | 12 | 5.15 | .330 | 1.46 | 9.2 | 4.0 | 4.2 | 197.1 | 202 | 124 | 113 | 33 | 87 | 92 | 0 | 0 | 0 | 0 | 14 | 3 | 4 | 5.61 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 83 | 0 | 8 | 7 | 3.41 | .298 | 1.27 | 7.1 | 4.3 | 10.0 | 129.1 | 102 | 54 | 49 | 13 | 62 | 144 | 0 | 8 | 5 | 0 | 0 | 1 | 0 | 3.54 |
| RP | Rivera, M.Rivera, Mariano # >> | 39 | 2008 | R | 85 | 80 | 0 | 6 | 2 | 4.41 | .281 | 1.15 | 8.4 | 2.0 | 8.4 | 104.0 | 97 | 54 | 51 | 15 | 23 | 97 | 0 | 10 | 3 | 0 | 0 | 2 | 4 | 3.73 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 60 | 0 | 4 | 1 | 3.82 | .324 | 1.41 | 8.3 | 4.4 | 8.6 | 66.0 | 61 | 28 | 28 | 9 | 32 | 63 | 0 | 5 | 1 | 0 | 0 | 2 | 4 | 4.41 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 49 | 0 | 1 | 2 | 5.53 | .337 | 1.52 | 10.9 | 2.9 | 9.4 | 68.1 | 82 | 42 | 42 | 9 | 22 | 71 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 3.60 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 20 | 0 | 2 | 0 | 5.96 | .325 | 1.40 | 9.0 | 4.0 | 7.6 | 25.2 | 25 | 18 | 17 | 4 | 11 | 21 | 0 | 3 | 1 | 0 | 0 | 1 | 2 | 4.84 |