| SP | Severino, L.Severino, Luis >> | 28 | 2022 | R | 92 | 12 | 12 | 4 | 6 | 4.21 | .311 | 1.34 | 8.2 | 4.0 | 11.0 | 66.1 | 60 | 32 | 31 | 8 | 29 | 81 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 3.48 |
| SP | Stripling, R.Stripling, Ross >> | 32 | 2022 | R | 72 | 12 | 12 | 4 | 5 | 4.24 | .280 | 1.13 | 8.5 | 1.7 | 6.9 | 57.1 | 54 | 28 | 27 | 13 | 11 | 44 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5.11 |
| SP | Skubal, T.Skubal, Tarik # >> | 25 | 2022 | L | 62 | 12 | 12 | 4 | 7 | 6.04 | .323 | 1.39 | 10.6 | 1.9 | 9.7 | 67.0 | 79 | 47 | 45 | 10 | 14 | 72 | 0 | 0 | 0 | 0 | 4 | 3 | 0 | 3.55 |
| SP | Kluber, C.Kluber, Corey >> | 36 | 2022 | R | 36 | 11 | 11 | 5 | 4 | 4.01 | .331 | 1.42 | 10.8 | 2.1 | 9.0 | 60.2 | 72 | 30 | 27 | 5 | 14 | 60 | 0 | 0 | 0 | 0 | 5 | 4 | 0 | 2.98 |
| RP | Minter, A.Minter, A.J. >> | 28 | 2022 | L | 92 | 34 | 0 | 2 | 2 | 3.18 | .261 | 1.06 | 8.0 | 1.6 | 12.0 | 45.1 | 40 | 16 | 16 | 6 | 8 | 60 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 2.60 |
| RP | Lamet, D.Lamet, Dinelson >> | 29 | 2022 | R | 25 | 40 | 0 | 1 | 2 | 4.02 | .288 | 1.19 | 5.9 | 5.0 | 9.7 | 40.1 | 26 | 18 | 18 | 5 | 22 | 43 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 4.20 |
| SP | Syndergaard, N.Syndergaard, Noah >> | 29 | 2022 | R | 26 | 11 | 0 | 2 | 0 | 7.63 | .361 | 1.70 | 10.2 | 5.4 | 9.0 | 15.1 | 17 | 13 | 13 | 3 | 9 | 15 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.40 |