| SP | Burnes, C.Burnes, Corbin # >> | 27 | 2022 | R | 94 | 18 | 18 | 6 | 9 | 4.53 | .306 | 1.28 | 9.0 | 2.5 | 10.4 | 113.1 | 113 | 58 | 57 | 15 | 32 | 130 | 0 | 0 | 0 | 0 | 10 | 5 | 3 | 3.41 |
| SP | Skubal, T.Skubal, Tarik >> | 25 | 2022 | L | 62 | 17 | 17 | 0 | 9 | 6.33 | .395 | 1.88 | 13.2 | 3.9 | 9.2 | 79.2 | 116 | 56 | 56 | 18 | 34 | 81 | 0 | 0 | 0 | 0 | 1 | 6 | 1 | 5.43 |
| RP | Bickford, P.Bickford, Phil >> | 26 | 2022 | R | 61 | 44 | 0 | 2 | 3 | 6.10 | .327 | 1.44 | 10.7 | 2.3 | 10.4 | 59.0 | 70 | 40 | 40 | 13 | 15 | 68 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 4.37 |
| RP | Farmer, B.Farmer, Buck >> | 31 | 2022 | R | 48 | 42 | 0 | 4 | 2 | 5.47 | .332 | 1.42 | 10.2 | 2.7 | 10.5 | 54.1 | 61 | 36 | 33 | 3 | 16 | 63 | 0 | 3 | 3 | 0 | 0 | 4 | 2 | 2.50 |
| RP | Velasquez, V.Velasquez, Vincent >> | 30 | 2022 | R | 37 | 36 | 0 | 4 | 3 | 4.05 | .323 | 1.38 | 9.2 | 3.2 | 8.4 | 73.1 | 75 | 33 | 33 | 6 | 26 | 68 | 0 | 3 | 2 | 0 | 0 | 4 | 0 | 3.44 |
| RP | Rogers, T.Rogers, Tyler >> | 31 | 2022 | R | 29 | 29 | 0 | 4 | 2 | 4.58 | .325 | 1.42 | 9.7 | 3.2 | 7.3 | 37.1 | 40 | 19 | 19 | 3 | 13 | 30 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.57 |
| SP | Sandoval, P.Sandoval, Patrick >> | 25 | 2022 | L | 30 | 2 | 0 | 0 | 0 | 16.62 | .480 | 2.77 | 18.0 | 9.0 | 9.0 | 4.1 | 8 | 8 | 8 | 2 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10.50 |
| SP | Eovaldi, N.Eovaldi, Nathan >> | 32 | 2022 | R | 38 | 15 | 0 | 1 | 0 | 2.92 | .315 | 1.34 | 9.0 | 3.4 | 7.1 | 24.2 | 24 | 8 | 8 | 7 | 9 | 19 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 6.46 |