| SP | Verlander, J.Verlander, Justin † >> | 39 | 2022 | R | 100 | 18 | 18 | 13 | 3 | 2.91 | .257 | 0.99 | 7.1 | 1.9 | 11.3 | 120.2 | 94 | 39 | 39 | 13 | 25 | 151 | 0 | 0 | 0 | 0 | 13 | 6 | 4 | 2.67 |
| SP | Rodon, C.Rodon, Carlos >> | 29 | 2022 | L | 89 | 17 | 17 | 6 | 5 | 5.26 | .335 | 1.49 | 9.6 | 3.9 | 12.5 | 90.2 | 96 | 58 | 53 | 14 | 39 | 125 | 0 | 0 | 0 | 0 | 7 | 2 | 3 | 3.61 |
| SP | Kopech, M.Kopech, Michael >> | 26 | 2022 | R | 69 | 16 | 16 | 5 | 3 | 6.01 | .353 | 1.55 | 9.7 | 4.3 | 8.1 | 73.1 | 79 | 49 | 49 | 14 | 35 | 66 | 0 | 0 | 0 | 0 | 2 | 6 | 1 | 5.37 |
| RP | Herget, J.Herget, Jimmy >> | 28 | 2022 | R | 86 | 47 | 0 | 5 | 3 | 3.33 | .313 | 1.28 | 8.6 | 3.0 | 8.1 | 70.1 | 67 | 27 | 26 | 7 | 23 | 63 | 0 | 1 | 3 | 0 | 0 | 6 | 0 | 3.74 |
| RP | Holmes, C.Holmes, Clay >> | 29 | 2022 | R | 73 | 41 | 0 | 2 | 1 | 3.12 | .304 | 1.23 | 8.1 | 2.9 | 11.6 | 52.0 | 47 | 19 | 18 | 4 | 17 | 67 | 0 | 2 | 1 | 0 | 0 | 4 | 2 | 2.63 |
| RP | Karinchak, J.Karinchak, James >> | 26 | 2022 | R | 81 | 36 | 0 | 3 | 0 | 2.56 | .293 | 1.19 | 6.6 | 4.3 | 12.1 | 38.2 | 28 | 16 | 11 | 5 | 18 | 51 | 0 | 0 | 3 | 0 | 0 | 2 | 5 | 3.61 |
| RP | Tepera, R.Tepera, Ryan >> | 34 | 2022 | R | 68 | 31 | 0 | 1 | 2 | 4.22 | .338 | 1.50 | 8.7 | 4.8 | 9.3 | 32.0 | 31 | 19 | 15 | 6 | 17 | 33 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 5.06 |
| RP | Alvarado, J.Alvarado, Jose >> | 27 | 2022 | L | 65 | 28 | 0 | 2 | 0 | 4.34 | .336 | 1.48 | 9.9 | 3.4 | 11.5 | 29.0 | 32 | 15 | 14 | 3 | 11 | 37 | 0 | 1 | 1 | 0 | 0 | 1 | 4 | 3.03 |
| SP | Greene, H.Greene, Hunter >> | 22 | 2022 | R | 67 | 7 | 1 | 1 | 3 | 4.67 | .350 | 1.62 | 9.5 | 5.3 | 11.6 | 17.1 | 18 | 10 | 9 | 4 | 10 | 22 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.24 |