| SP | Cortes Jr., N.Cortes Jr., Nestor >> | 27 | 2022 | L | 97 | 18 | 18 | 4 | 9 | 3.88 | .289 | 1.21 | 7.8 | 3.2 | 9.8 | 111.1 | 96 | 48 | 48 | 13 | 39 | 121 | 1 | 0 | 0 | 1 | 8 | 1 | 1 | 3.42 |
| SP | Alcantara, S.Alcantara, Sandy † >> | 26 | 2022 | R | 85 | 17 | 17 | 9 | 4 | 3.16 | .288 | 1.18 | 8.6 | 2.0 | 7.1 | 128.0 | 122 | 48 | 45 | 10 | 29 | 101 | 2 | 0 | 0 | 2 | 12 | 4 | 3 | 3.21 |
| SP | Anderson, T.Anderson, Tyler >> | 32 | 2022 | L | 80 | 17 | 17 | 9 | 2 | 5.17 | .313 | 1.35 | 9.3 | 2.9 | 8.3 | 101.0 | 104 | 58 | 58 | 11 | 32 | 93 | 0 | 0 | 0 | 0 | 7 | 2 | 2 | 3.58 |
| SP | Valdez, F.Valdez, Framber >> | 28 | 2022 | L | 71 | 16 | 16 | 3 | 6 | 5.99 | .379 | 1.80 | 11.1 | 5.2 | 7.1 | 97.2 | 120 | 73 | 65 | 13 | 56 | 76 | 0 | 0 | 0 | 0 | 5 | 3 | 4 | 5.00 |
| SP | Wacha, M.Wacha, Michael # >> | 30 | 2022 | R | 67 | 16 | 16 | 7 | 6 | 4.60 | .325 | 1.39 | 10.0 | 2.5 | 8.5 | 90.0 | 100 | 50 | 46 | 14 | 25 | 85 | 0 | 0 | 0 | 0 | 7 | 5 | 2 | 4.13 |
| CL | Sewald, P.Sewald, Paul >> | 32 | 2022 | R | 96 | 39 | 0 | 2 | 6 | 3.38 | .264 | 1.05 | 7.7 | 1.8 | 8.1 | 40.0 | 34 | 15 | 15 | 4 | 8 | 36 | 0 | 19 | 2 | 0 | 0 | 1 | 0 | 3.18 |
| SU | Hentges, S.Hentges, Sam † >> | 25 | 2022 | L | 91 | 44 | 0 | 6 | 0 | 2.08 | .235 | 0.90 | 4.8 | 3.4 | 9.2 | 47.2 | 25 | 11 | 11 | 2 | 18 | 48 | 0 | 2 | 2 | 0 | 0 | 1 | 3 | 2.72 |
| RP | Romano, J.Romano, Jordan >> | 29 | 2022 | R | 80 | 46 | 0 | 1 | 5 | 4.57 | .337 | 1.46 | 8.4 | 4.8 | 8.8 | 45.1 | 42 | 23 | 23 | 3 | 24 | 44 | 0 | 1 | 1 | 0 | 0 | 3 | 0 | 3.71 |
| RP | Garcia, Y.Garcia, Yimi >> | 31 | 2022 | R | 67 | 37 | 0 | 4 | 0 | 3.57 | .313 | 1.29 | 9.2 | 2.5 | 10.1 | 40.1 | 41 | 16 | 16 | 4 | 11 | 45 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 3.10 |