| SP | McKenzie, T.McKenzie, Triston >> | 24 | 2022 | R | 93 | 3 | 3 | 1 | 0 | 3.05 | .271 | 1.11 | 9.0 | 1.4 | 7.2 | 20.2 | 20 | 8 | 7 | 2 | 3 | 16 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 3.15 |
| SP | Woodruff, B.Woodruff, Brandon >> | 29 | 2022 | R | 83 | 2 | 2 | 1 | 0 | 5.73 | .365 | 1.73 | 12.3 | 3.3 | 12.3 | 11.0 | 15 | 7 | 7 | 3 | 4 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.91 |
| SP | Skubal, T.Skubal, Tarik >> | 25 | 2022 | L | 62 | 2 | 2 | 0 | 0 | 0.69 | .278 | 1.08 | 2.8 | 6.9 | 7.6 | 13.0 | 4 | 1 | 1 | 0 | 10 | 11 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 3.85 |
| RP | Bautista, F.Bautista, Félix >> | 27 | 2022 | R | 95 | 7 | 0 | 0 | 2 | 8.00 | .341 | 1.56 | 13.0 | 1.0 | 10.0 | 9.0 | 13 | 8 | 8 | 3 | 1 | 10 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.44 |
| RP | Jimenez, J.Jimenez, Joe >> | 27 | 2022 | R | 63 | 5 | 0 | 2 | 0 | 2.45 | .290 | 1.23 | 6.4 | 5.1 | 11.6 | 7.1 | 5 | 2 | 2 | 1 | 4 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Tepera, R.Tepera, Ryan >> | 34 | 2022 | R | 68 | 4 | 0 | 0 | 0 | 2.25 | .333 | 1.50 | 4.5 | 9.0 | 4.5 | 4.0 | 2 | 1 | 1 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.00 |
| SP | Kelly, M.Kelly, Merrill >> | 33 | 2022 | R | 71 | 4 | 2 | 0 | 0 | 3.68 | .279 | 1.16 | 10.3 | 0.6 | 6.4 | 14.2 | 16 | 6 | 6 | 0 | 1 | 10 | 0 | 2 | 0 | 0 | 1 | 0 | 1 | 1.79 |