| SP | Gallen, Z.Gallen, Zac # >> | 26 | 2022 | R | 99 | 18 | 18 | 6 | 2 | 2.89 | .279 | 1.13 | 7.7 | 2.5 | 10.0 | 115.1 | 98 | 38 | 37 | 8 | 32 | 128 | 0 | 0 | 0 | 0 | 14 | 4 | 3 | 2.62 |
| SP | Ohtani, S.Ohtani, Shohei >> | 27 | 2022 | R | 89 | 17 | 17 | 7 | 4 | 3.86 | .330 | 1.44 | 8.4 | 4.5 | 10.7 | 93.1 | 87 | 44 | 40 | 9 | 47 | 111 | 0 | 0 | 0 | 0 | 9 | 4 | 4 | 3.52 |
| SP | Castillo, L.Castillo, Luis >> | 29 | 2022 | R | 82 | 17 | 17 | 7 | 4 | 4.26 | .313 | 1.34 | 8.7 | 3.3 | 9.2 | 95.0 | 92 | 45 | 45 | 11 | 35 | 97 | 0 | 0 | 0 | 0 | 9 | 3 | 0 | 3.66 |
| SP | Darvish, Y.Darvish, Yu >> | 35 | 2022 | R | 91 | 16 | 16 | 6 | 7 | 4.26 | .329 | 1.41 | 9.7 | 3.0 | 9.0 | 93.0 | 100 | 44 | 44 | 12 | 31 | 93 | 0 | 0 | 0 | 0 | 8 | 6 | 1 | 3.87 |
| CL | Helsley, R.Helsley, Ryan † >> | 27 | 2022 | R | 100 | 43 | 0 | 3 | 3 | 2.08 | .227 | 0.86 | 5.2 | 2.7 | 10.9 | 47.2 | 27 | 11 | 11 | 4 | 14 | 57 | 0 | 23 | 0 | 0 | 0 | 1 | 0 | 2.64 |
| RP | Schreiber, J.Schreiber, John >> | 28 | 2022 | R | 85 | 46 | 0 | 3 | 1 | 1.94 | .273 | 1.09 | 6.9 | 3.0 | 10.2 | 60.1 | 46 | 14 | 13 | 4 | 20 | 68 | 0 | 1 | 1 | 0 | 0 | 2 | 3 | 2.70 |
| RP | Ottavino, A.Ottavino, Adam >> | 36 | 2022 | R | 82 | 46 | 0 | 5 | 1 | 4.28 | .325 | 1.43 | 9.8 | 3.2 | 11.0 | 54.2 | 59 | 28 | 26 | 7 | 19 | 66 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 3.35 |
| RP | Hendriks, L.Hendriks, Liam >> | 33 | 2022 | R | 74 | 38 | 0 | 5 | 0 | 5.18 | .290 | 1.22 | 8.1 | 3.1 | 10.5 | 41.2 | 37 | 24 | 24 | 9 | 14 | 48 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.54 |
| RP | Bednar, D.Bednar, David >> | 27 | 2022 | R | 64 | 37 | 0 | 3 | 1 | 4.89 | .333 | 1.40 | 9.2 | 3.6 | 8.3 | 38.2 | 39 | 21 | 21 | 8 | 15 | 35 | 0 | 2 | 0 | 0 | 0 | 4 | 0 | 5.39 |