| SP | Verlander, J.Verlander, Justin >> | 39 | 2022 | R | 100 | 12 | 12 | 8 | 0 | 2.35 | .267 | 1.06 | 6.9 | 2.7 | 9.2 | 84.1 | 64 | 22 | 22 | 5 | 25 | 86 | 1 | 0 | 0 | 1 | 8 | 3 | 3 | 2.73 |
| SP | Ohtani, S.Ohtani, Shohei >> | 27 | 2022 | R | 89 | 12 | 12 | 6 | 4 | 4.50 | .307 | 1.30 | 8.4 | 3.3 | 10.7 | 70.0 | 65 | 36 | 35 | 11 | 26 | 83 | 0 | 0 | 0 | 0 | 7 | 2 | 4 | 3.87 |
| SP | Wheeler, Z.Wheeler, Zack >> | 32 | 2022 | R | 82 | 12 | 12 | 5 | 2 | 5.74 | .351 | 1.57 | 11.2 | 2.9 | 9.5 | 69.0 | 86 | 44 | 44 | 11 | 22 | 73 | 0 | 0 | 0 | 0 | 4 | 4 | 3 | 4.09 |
| SP | Snell, B.Snell, Blake # >> | 29 | 2022 | L | 70 | 12 | 12 | 6 | 1 | 4.82 | .342 | 1.45 | 9.8 | 3.3 | 9.0 | 65.1 | 71 | 35 | 35 | 4 | 24 | 65 | 0 | 0 | 0 | 0 | 3 | 7 | 4 | 3.23 |
| SP | Luzardo, J.Luzardo, Jesus >> | 24 | 2022 | L | 88 | 11 | 11 | 8 | 1 | 1.38 | .229 | 0.87 | 5.5 | 2.4 | 10.6 | 71.2 | 43 | 12 | 11 | 6 | 19 | 84 | 1 | 0 | 0 | 1 | 7 | 2 | 0 | 2.62 |
| RP | Jansen, K.Jansen, Kenley >> | 34 | 2022 | R | 79 | 33 | 0 | 4 | 0 | 0.86 | .256 | 1.03 | 5.0 | 4.4 | 9.0 | 41.2 | 23 | 4 | 4 | 1 | 20 | 41 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 2.78 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 30 | 2022 | R | 80 | 23 | 0 | 4 | 0 | 1.95 | .297 | 1.16 | 7.3 | 3.3 | 8.3 | 27.2 | 22 | 6 | 6 | 1 | 10 | 25 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 3.07 |
| RP | Holmes, C.Holmes, Clay >> | 29 | 2022 | R | 73 | 17 | 0 | 1 | 1 | 4.00 | .280 | 1.00 | 7.5 | 1.5 | 11.0 | 18.0 | 15 | 8 | 8 | 2 | 3 | 22 | 0 | 0 | 1 | 0 | 0 | 3 | 1 | 3.00 |
| RP | Thielbar, C.Thielbar, Caleb >> | 35 | 2022 | L | 60 | 16 | 0 | 2 | 1 | 1.56 | .246 | 0.98 | 5.3 | 3.7 | 10.6 | 17.1 | 10 | 3 | 3 | 2 | 7 | 20 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.41 |
| RP | Chafin, A.Chafin, Andrew >> | 32 | 2022 | L | 57 | 12 | 0 | 0 | 1 | 3.86 | .323 | 1.43 | 10.3 | 2.6 | 13.5 | 14.0 | 16 | 6 | 6 | 1 | 4 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.79 |
| SU | Hentges, S.Hentges, Sam >> | 25 | 2022 | L | 91 | 24 | 0 | 0 | 1 | 4.10 | .319 | 1.33 | 8.7 | 3.5 | 10.4 | 26.1 | 25 | 12 | 12 | 4 | 10 | 30 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 4.08 |
| CL | Helsley, R.Helsley, Ryan >> | 27 | 2022 | R | 100 | 25 | 0 | 2 | 1 | 1.46 | .260 | 0.93 | 5.3 | 3.4 | 9.4 | 24.2 | 14 | 4 | 4 | 3 | 9 | 25 | 0 | 18 | 2 | 0 | 0 | 3 | 0 | 4.04 |
| SP | Archer, C.Archer, Chris >> | 33 | 2022 | R | 42 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |