| SP | Scott, M.Scott, Mike † # >> | 31 | 1986 | R | 92 | 23 | 23 | 14 | 4 | 3.18 | .274 | 1.12 | 7.6 | 2.5 | 8.1 | 164.1 | 139 | 59 | 58 | 16 | 45 | 147 | 4 | 0 | 0 | 3 | 16 | 2 | 3 | 3.34 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 90 | 22 | 22 | 11 | 7 | 3.82 | .288 | 1.20 | 9.1 | 1.7 | 6.6 | 153.1 | 155 | 70 | 65 | 24 | 29 | 112 | 6 | 0 | 0 | 1 | 10 | 2 | 0 | 4.18 |
| SP | Perry, G.Perry, Gaylord † >> | 34 | 1972 | R | 69 | 21 | 21 | 14 | 4 | 3.80 | .307 | 1.30 | 8.3 | 3.4 | 6.8 | 144.1 | 132 | 67 | 61 | 19 | 55 | 108 | 3 | 0 | 0 | 0 | 12 | 5 | 5 | 4.47 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 92 | 53 | 0 | 3 | 5 | 3.98 | .288 | 1.18 | 6.7 | 4.0 | 9.2 | 54.1 | 40 | 24 | 24 | 7 | 24 | 55 | 0 | 30 | 3 | 0 | 0 | 2 | 1 | 4.09 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 50 | 0 | 1 | 2 | 3.99 | .332 | 1.49 | 9.5 | 4.0 | 10.3 | 56.1 | 59 | 27 | 25 | 8 | 25 | 64 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.91 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 44 | 0 | 3 | 2 | 3.40 | .260 | 1.04 | 7.8 | 1.5 | 10.7 | 53.0 | 46 | 23 | 20 | 6 | 9 | 63 | 0 | 5 | 2 | 0 | 0 | 1 | 1 | 2.66 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 33 | 0 | 3 | 0 | 3.66 | .351 | 1.59 | 9.3 | 5.1 | 9.8 | 32.0 | 33 | 17 | 13 | 3 | 18 | 35 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.81 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 25 | 0 | 1 | 2 | 3.75 | .327 | 1.46 | 7.1 | 6.0 | 10.1 | 24.0 | 19 | 10 | 10 | 3 | 16 | 27 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4.38 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 70 | 24 | 0 | 1 | 0 | 2.86 | .254 | 0.99 | 5.1 | 3.9 | 10.0 | 28.1 | 16 | 10 | 9 | 2 | 12 | 31 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.11 |