| SP | Scherzer, M.Scherzer, Max >> | 38 | 2022 | R | 98 | 12 | 12 | 5 | 1 | 3.38 | .294 | 1.20 | 8.1 | 2.7 | 9.8 | 80.0 | 72 | 32 | 30 | 6 | 24 | 87 | 0 | 0 | 0 | 0 | 7 | 4 | 0 | 2.85 |
| SP | Fernandez, S.Fernandez, Sid >> | 26 | 1988 | L | 91 | 12 | 12 | 5 | 4 | 4.46 | .298 | 1.22 | 6.4 | 4.6 | 10.3 | 70.2 | 50 | 35 | 35 | 8 | 36 | 80 | 0 | 0 | 0 | 0 | 8 | 4 | 2 | 3.91 |
| SP | Koosman, J.Koosman, Jerry >> | 34 | 1976 | L | 66 | 13 | 11 | 5 | 4 | 5.35 | .312 | 1.34 | 9.7 | 2.5 | 6.0 | 77.1 | 83 | 49 | 46 | 16 | 21 | 51 | 1 | 1 | 0 | 0 | 5 | 1 | 2 | 5.23 |
| RP | deGrom, J.deGrom, Jacob >> | 34 | 2022 | R | 98 | 35 | 0 | 1 | 1 | 2.84 | .283 | 1.13 | 6.2 | 4.0 | 10.9 | 38.0 | 26 | 12 | 12 | 2 | 17 | 46 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 2.76 |
| RP | Lockwood, S.Lockwood, Skip >> | 30 | 1976 | R | 76 | 23 | 0 | 0 | 2 | 3.56 | .289 | 1.19 | 6.9 | 3.9 | 9.3 | 30.1 | 23 | 12 | 12 | 3 | 13 | 31 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 3.63 |
| RP | Ottavino, A.Ottavino, Adam >> | 36 | 2022 | R | 73 | 22 | 0 | 2 | 0 | 4.22 | .312 | 1.31 | 7.7 | 4.3 | 8.1 | 21.1 | 18 | 10 | 10 | 4 | 10 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.24 |
| SP | Matlack, J.Matlack, Jon >> | 26 | 1976 | L | 45 | 3 | 0 | 1 | 0 | 6.35 | .382 | 1.76 | 12.3 | 4.1 | 2.5 | 11.1 | 15 | 8 | 8 | 6 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 11.18 |