| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 13 | 13 | 5 | 5 | 5.40 | .306 | 1.28 | 8.3 | 3.2 | 8.2 | 65.0 | 60 | 39 | 39 | 8 | 23 | 59 | 0 | 0 | 0 | 0 | 5 | 3 | 1 | 3.98 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 77 | 12 | 12 | 6 | 4 | 3.73 | .281 | 1.16 | 8.2 | 2.2 | 5.7 | 82.0 | 75 | 35 | 34 | 7 | 20 | 52 | 0 | 0 | 0 | 0 | 7 | 1 | 1 | 3.61 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 88 | 12 | 12 | 6 | 4 | 3.98 | .315 | 1.34 | 9.3 | 2.8 | 9.1 | 81.1 | 84 | 40 | 36 | 12 | 25 | 82 | 2 | 0 | 0 | 1 | 7 | 3 | 0 | 3.94 |
| SP | Maddux, G.Maddux, Greg # >> | 34 | 2000 | R | 57 | 11 | 8 | 2 | 5 | 4.43 | .320 | 1.39 | 9.4 | 3.1 | 4.9 | 61.0 | 64 | 34 | 30 | 5 | 21 | 33 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 4.07 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 76 | 21 | 0 | 1 | 1 | 1.32 | .261 | 1.02 | 7.3 | 2.0 | 10.7 | 27.1 | 22 | 4 | 4 | 2 | 6 | 32 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.37 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 62 | 20 | 0 | 1 | 1 | 2.79 | .301 | 1.19 | 6.2 | 4.7 | 5.2 | 19.1 | 13 | 6 | 6 | 4 | 10 | 11 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 6.47 |
| SU | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 86 | 21 | 0 | 2 | 1 | 2.82 | .264 | 1.03 | 6.5 | 2.9 | 9.8 | 22.1 | 16 | 7 | 7 | 1 | 7 | 24 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 2.50 |
| CL | Wheeler, D.Wheeler, Dan >> | 32 | 2009 | R | 67 | 19 | 0 | 1 | 0 | 1.71 | .250 | 0.95 | 7.3 | 1.3 | 9.0 | 21.0 | 17 | 7 | 4 | 2 | 3 | 21 | 0 | 5 | 0 | 0 | 0 | 1 | 1 | 2.81 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 84 | 25 | 0 | 1 | 3 | 3.38 | .294 | 1.25 | 7.9 | 3.4 | 4.8 | 32.0 | 28 | 12 | 12 | 3 | 12 | 17 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 4.28 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 90 | 20 | 0 | 0 | 1 | 4.18 | .317 | 1.39 | 9.8 | 3.1 | 9.4 | 23.2 | 25 | 11 | 11 | 3 | 8 | 24 | 0 | 5 | 1 | 0 | 0 | 0 | 1 | 3.65 |
| RP | Takatsu, S.Takatsu, Shingo >> | 36 | 2004 | R | 55 | 7 | 0 | 0 | 0 | 5.68 | .321 | 1.42 | 12.0 | 1.5 | 6.0 | 6.1 | 8 | 6 | 4 | 3 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8.67 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 67 | 9 | 3 | 2 | 0 | 6.75 | .367 | 1.68 | 11.5 | 3.8 | 7.6 | 33.1 | 42 | 26 | 25 | 5 | 14 | 28 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 4.73 |